Release of Matrix Metalloproteinases by Macrophages in Radicular Cysts and Residual Radicular Cysts

França, Glória M; Medeiros, Cristianne K S; Almeida, Dennys R M F; Pinheiro, Juliana C; Andrade, Ana Luiza Dias Leite de; Santos, Pedro Paulo Albino dos; Galvão, Hébel Cavalcanti

doi:10.1097/pai.0000000000001005

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Higher immunoexpression of MMP-13 and MMP-9 is observed in the early stages of Radicular Cysts compared with Residual Cysts. Therefore, the toxins of microorganisms present in highly inflamed Radicular Cysts are the main factors triggering a proinflammatory immune response and greater cystic expansion in the early stages of these lesions [19].…”

Section: Discussionmentioning

confidence: 99%

Treatment Approache for Odontogenic Cysts in the Maxilla

Arsovska

Terzievski²,

Simjanovska

et al. 2022

JMS

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A cyst is defined as a pathological cavity lined by epithelium and the lumen is filled with cystic contents. The epithelium itself is surrounded by fibrocollagenous connective tissue and may be derived from various sources. Cysts are usually associated with carious, nonvital, discolored, or fractured teeth and are found mostly at the apices of the teeth. Radiologically, it arises from the apex of the root of a carious tooth and is bounded by a thin rim of cortical bone.They rarely become problematic and are incidentally found on routine dental radiographs. As they appear to reach a considerable size prior to medical attention due to their insidious and destructive growth characteristics during the intraosseous stage, treatment often requires extensive cystectomy and skeletal reconstruction.This case report shows the treatment of a big radicular cyst in the maxilla. After surgical enucleation and biopsy, histopathological picture revealed fragments of sections of a collagen cyst wall lined with multilayered squamous epithelium which were seen microscopically. Scarce inflammation is present. Immunohistochemically was found focal CD20+ lymphoid accumulations (up to 40%) with CD3+ T lymphocytes up to 60% of which a significant part is CD40+, and 10% CD8+, CD68 mark the reduced pres ence of resident histiocytes (up to 5%).The finding confirmed the presence of a chronically inflamed radicular cyst. The diagnosis of a cyst, in addition to clinical and paraclinical examinations must be confirmed by the pathohistological findings.

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Section: Discussionmentioning

confidence: 99%

Treatment Approache for Odontogenic Cysts in the Maxilla

Arsovska

Terzievski²,

Simjanovska

et al. 2022

JMS

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About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

Ciani,

Libonati,

Dri

et al. 2024

IJMS

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Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well as in oral premalignant lesions, where they exert pro-tumorigenic activities. Since the two bacteria are present also in endodontic diseases, playing a role in their pathogenesis, here we analyze the literature searching for information on the impact that endodontic infection by P. gingivalis or F. nucleatum could have on cellular and molecular events involved in oral carcinogenesis. Results from the reviewed papers indicate that infection by P. gingivalis and/or F. nucleatum triggers the production of inflammatory cytokines and growth factors in dental pulp cells or periodontal cells, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. In addition, the two bacteria and the cytokines they induce halt the differentiation and stimulate the proliferation and invasion of stem cells populating the dental pulp or the periodontium. Although most of the literature confutes the possibility that bacteria-induced endodontic inflammatory diseases could impact on oral carcinogenesis, the papers we have analyzed and discussed herein recommend further investigations on this topic.

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Release of Matrix Metalloproteinases by Macrophages in Radicular Cysts and Residual Radicular Cysts

Cited by 2 publications

References 33 publications

Treatment Approache for Odontogenic Cysts in the Maxilla

Treatment Approache for Odontogenic Cysts in the Maxilla

About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview

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