Release of Glutamate in the Nucleus Tractus Solitarii in Response to Baroreflex Activation in Rats

Ohta, Hisashi; Li, X; Talman, William T.

doi:10.1016/0306-4522(96)00113-3

Cited by 43 publications

(17 citation statements)

References 26 publications

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“…One means of showing that presynaptic neurons may contain glutamate as a transmitter was measurement of its high affinity uptake into those cells while another was measurement of the amino acid released from those neurons. While some studies had shown both uptake (Talman et al, 1980) and release of glutamate (Ohta et al, 1996), the presence of glutamate in baroreceptor afferents was questioned when other studies failed to show a change in high affinity glutamate uptake in the NTS and a lack of significant change in glutamate levels in dialysate from the NTS after depolarization when the NG had been removed (Sved, 1986;Sved and Curtis, 1993). Furthermore, because bilateral microinjection of the excitatory amino acid receptor antagonist kynurenic acid did not reduce cardiovascular responses produced by injection of glutamate into the NTS, some raised the possibility that an excitatory amino acid or its analog other than glutamate may be the neurotransmitter released at baroreceptor terminals in the NTS (Leone and Gordon, 1989).…”

Section: Discussionmentioning

confidence: 98%

Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons

Lin

Talman

2006

Journal of Chemical Neuroanatomy

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Section: Discussionmentioning

confidence: 98%

Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons

Lin

Talman

2006

Journal of Chemical Neuroanatomy

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“…Other studies have also shown that glutamate is released in the NTS during stimulation with high potassium levels in vitro and in vivo as well as during electrical stimulation of the vagus afferent in vivo (25)(26)(27)(28). More recently, studies by Ohta et al (29) have shown that activation of the baroreflex releases L-glutamate in the NTS.…”

Section: Introductionmentioning

confidence: 92%

Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii

Machado

Mauad²,

Chianca³

et al. 1997

Braz J Med Biol Res

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The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated. In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo-and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the pressor response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.

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“…We measured the urinary norepinephrine concentration before and 7 days after the gene transfer by high-performance liquid chromatography, and we calculated the urinary to be a major neurotransmitter of baroreceptor primary afferent fibers (9,10). In addition, neuronal NOS (nNOS) has been demonstrated to be highly expressed in the NTS (11).…”

Section: Measurement Of Urinary Norepinephrine Excretionmentioning

confidence: 99%

Enhanced Depressor Response to Endothelial Nitric Oxide Synthase Gene Transfer into the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats

et al. 2003

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Previously, we demonstrated that endothelial nitric oxide synthase (eNOS) gene transfer into the nucleus tractus solitarii (NTS) decreased blood pressure, heart rate and sympathetic nerve activity in conscious normotensive Wistar-Kyoto rats (WKY). In order to determine whether overexpression of eNOS in the NTS causes different effects on blood pressure and heart rate between spontaneously hypertensive rats (SHR) and WKY, we transfected adenovirus vectors encoding either eNOS (AdeNOS

show abstract

Release of Glutamate in the Nucleus Tractus Solitarii in Response to Baroreflex Activation in Rats

Cited by 43 publications

References 26 publications

Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons

Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons

Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii

Enhanced Depressor Response to Endothelial Nitric Oxide Synthase Gene Transfer into the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats

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