Release of fragmented host, cell-free, genomic DNA into the circulation of pigs during infection by virulent African swine fever virus
Ann Sofie Olesen,
Louise Lohse,
Camille Melissa Johnston
et al.
Abstract:African swine fever virus (ASFV) causes a severe hemorrhagic disease in domestic pigs resulting in high case fatality rates. The virus replicates in circulating cells of the monocyte-macrophage lineage and within lymphoid tissues, e.g. tonsils, spleen and lymph nodes. The infection results in high fever and a variety of clinical signs from about 3 days post infection. In this study, it was observed that one of many changes resulting from ASFV-infection within pigs was a large (>1000-fold) increase in the le… Show more
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