Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel

Masyruroh, Siti Fikroh; Lasmawati, Deudeu; Suryani, Nani; Sumarlin, La Ode; Nurlidar, Farah

doi:10.1063/5.0030348

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Ciprofloxacin was used as a model antibiotic to study the release properties of the PEDGA/CS hydrogels obtained by γ-irradiation. At 150 min, the cumulative release of PEDGA/ciprofloxacin and PEDGA/CS/ciprofloxacin hydrogels at an irradiation dose of 25 kGy were 87.96 ± 0.83% and 97.34 ± 0.41%, respectively [80]. In vitro cumulative release of sericin from the PVA hydrogels in PBS solution at 37 • C demonstrated that the sericin (50-70%) was released from the hydrogels within 6 h [147].…”

Section: Drug Releasementioning

confidence: 95%

“…Furthermore, as aforementioned in Section 2.2.1, the inclusion of levofloxacin HCl decreased the viscosity of prepared ISGS. The nucleation and growth mechanism of the polymer in the dilute phase gives rise to the phase separation process, and the spinodal de-mixing that occurs during the membrane formation process is responsible for the interconnectivity that Gels 2023, 9, 583 develops between the membranes [80]. Changes in solution viscosity caused by the addition of a hydrophilic drug could alter the phase separation rate, which ultimately causes the differences in matrix morphology as aforementioned for the addition of polyvinyl pyrrolidone (PVP) for producing polyethersulfone hollow fiber membranes [81].…”

Section: Drug Content and Release Of Levofloxacin Hcl-loaded Eudragit...mentioning

confidence: 99%

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Properties and Applications of Biomaterials Related to Gels

2023

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As an excellent biopolymer material, hydrogel has been widely used in drug delivery, tissue engineering, and disease treatment, among other applications. By combining different polymers through physical or chemical changes, the prepared hydrogels can show better performance and be used in various environments.At present, the exploration of hydrogel in biomedicine seems to be diversified. To adapt to the complex environment in organisms, higher requirements must put forward for hydrogel. Under the premise that hydrogel is biosafe, it must become tougher or more easily degradable according to the purpose of its application, be able to stay in the body for a longer time to exert its effect, or be easily removed. Moreover, certain hydrogels can respond to changes in pH, temperature, biological indicators, or microorganisms in the body. We are interested in the intelligent properties of hydrogels, and the condition in which these properties can be used to facilitate their applications is undoubtedly a question that researchers need to consider carefully. This reprint consists of 12 papers, of which 2 are editorials and 10 are research papers. We hope to share the experimental and research results in this field and inspire new ideas for the design and applications of hydrogels.

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Section: Drug Releasementioning

confidence: 95%

Section: Drug Content and Release Of Levofloxacin Hcl-loaded Eudragit...mentioning

confidence: 99%

Properties and Applications of Biomaterials Related to Gels

2023

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A simple method for the simultaneous encapsulation of ciprofloxacin into PEGDA/alginate hydrogels using gamma irradiation

Nurlidar

Rahayu

Lasmawati

et al. 2023

Arabian Journal of Chemistry

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State of the Art of Hydrogel Wound Dressings Developed by Ionizing Radiation

Demeter

Scărișoreanu

Călina

2023

Gels

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The development of an ideal hydrogel wound dressing with excellent characteristics is currently a significant demand in wound therapy. The ideal hydrogel wound dressing must provide a moist environment between the wound and the dressing, promote wound healing, absorb excess exudate and toxins, be completely sterile, and not adhere to the wound. The evolution and current status of research on hydrogel wound dressings obtained exclusively through production by ionizing radiation are discussed in this paper review, along with the preparation methods, properties, standard characterization techniques, and their applications in wound dressing. First, we described the methods for synthesizing hydrogel wound dressings with ionizing radiation. Then, standard methods of characterization of hydrogel wound dressings such as gel fraction, swelling degree, sol–gel analysis, rheological properties, morphology, moisture retention capability, and water vapor transmission rate have been investigated. In the end, specific attention was paid to the drug release, antibacterial performance, and cytotoxicity of hydrogels. Moreover, the application of hydrogel in regenerative medicine as wound healing dressing was covered.

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Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel

Cited by 3 publications

References 16 publications

Properties and Applications of Biomaterials Related to Gels

Properties and Applications of Biomaterials Related to Gels

A simple method for the simultaneous encapsulation of ciprofloxacin into PEGDA/alginate hydrogels using gamma irradiation

State of the Art of Hydrogel Wound Dressings Developed by Ionizing Radiation

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