Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis

Hsu, Jen-Hao; Wu, Yang‐Chang; Liu, I-Min; Cheng, Juei‐Tang

doi:10.1016/j.neulet.2006.05.025

Cited by 46 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The next 11~40 min was a period of perfusion with glucose stimulation. The stimulation-secretion coupling process in the pancreatic β-cells is affected by glucose (Curry, 1986; Rossetti et al, 1990; Yki-Jarvenen, 1992) as well as amino acids (Strandgaard & Curry, 1998), manganase (Baly et al, 1984), magnesium (Curry et al, 1977), calcium (Choi, 1997), fatty acid (Brockman, 1982; Nolan et al, 2006), cinnamic acid (Adsakwattana et al, 2008; Yibchok-anun et al, 2008), and oleanolic acid (Hsu et al, 2006). Therefore, the biochemical environment of the pancreas may modulate the insulin secretion from the pancreas (Pørksen et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats

Nam

Choi

2008

Nutr Res Pract

View full text Add to dashboard Cite

Cassia tora L. seeds have previously been reported to reduce blood glucose level in human and animals with diabetes. In the present study, the effects of Cassia tora L. seed butanol fraction (CATO) were studied on postprandial glucose control and insulin secretion from the pancreas of the normal and diabetic rats. Diabetes was induced by an i.p. injection of Streptozotocin (55 mg/kg BW) into the male Sprague-Dawley rats. The postprandial glucose control was monitored during a 240 min-period using a maltose loading test. In normal rats, rats fed CATO (20 mg/100 g BW/d) showed lower postprandial glucose levels in all the levels from 30 min up to 180 min than those in the control rats without CATO (p<0.05). In diabetic rats, those levels in the CATO group seemed to be lower during the 30~180 min, but only glucose level at 30 min showed significant difference compared to that in the control group. Moreover, CATO delayed the peak time of the glucose rise in both normal and diabetic rats in the glucose curves. On the other hand, when CATO was administered orally to the diabetic rats for 5 days, 12 hr fasting serum glucose level was decreased in the diabetic rats (p<0.05). Degree of a decrease in 12 hr fasting serum insulin levels was significantly less in the diabetic CATO rats as compared to diabetic control rats. On the last day of feeding, β cells of the pancreas were stimulated by 200 mg/dL glucose through a 40 min-pancreas perfusion. Amounts of the insulin secreted from the pancreas during the first phase (11~20 min) and the second phase (21~40 min) in the CATO fed diabetic rats were significantly greater than those in the diabetic control group (p<0.05). These findings indicated that constituents of Cassia tora L. seeds have beneficial effect on postprandial blood glucose control which may be partially mediated by stimulated insulin secretion from the pancreas of the diabetic rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats

Nam

Choi

2008

Nutr Res Pract

View full text Add to dashboard Cite

show abstract

“…In Wistar rats, the intraperitoneal injection of OA reduced fasting glycemia in parallel with the increase of plasma insulin (18). These actions were abolished by hemicholinium-3 and vesamicol, inhibitors of the choline uptake and acetylcholine transport, respectively, indicating that OA raises acetylcholine release from nerve terminals.…”

Section: Improvement Of Pancreatic β-Cell Function and Integritymentioning

confidence: 99%

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

et al. 2013

View full text Add to dashboard Cite

Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival of β-cells, and protects against diabetes complications. OA may directly modulate enzymes connected to insulin biosynthesis, secretion, and signaling. However, its major contributions appear to be derived from the interaction with important transduction pathways, and many of its effects are consistently related to activation of the transcription factor Nrf2. Doing that, OA induces the expression of antioxidant enzymes and phase II response genes, blocks NF-κB, and represses the polyol pathway, AGEs production, and hyperlipidemia. The management of type 2 diabetes requires an integrated approach, which includes the early intervention to prevent or delay the disease progression, and the use of therapies to control glycemia and lipidemia in its late stages. In this sense, the use of functional foods or drugs containing OA is, undoubtedly, an interesting path.

show abstract

“…This triterpenoid has been widely utilized in most parts of Asia for treating various ailments . Oleanolic acid has been shown to possess anti-inflammatory, anti-tumour, hepatoprotective, hypoglycemic, anti-hyperlipidemic and anti-oxidant properties (Liu, 1995;Hsu et al, 2006;Tong et al, 2011). Inhibition of reactive oxygen species formation protects against cell death .…”

Section: Introductionmentioning

confidence: 99%

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

2015

View full text Add to dashboard Cite

Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis

Cited by 46 publications

References 17 publications

Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats

Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

Contact Info

Product

Resources

About