Release mechanisms for polyelectrolyte capsules

Geest, Bruno G. De; Sanders, Niek N.; Sukhorukov, Gleb B.; Demeester, Joseph; Smedt, Stefaan C. De

doi:10.1039/b600460c

Cited by 464 publications

(319 citation statements)

References 170 publications

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“…The use of CaCO 3 as sacrificial template for capsule fabrication makes the capsules ideally suited for applications in the drug delivery field. In our ongoing research, the capsules will be used for transdermal [34] activated drug release. …”

Section: Resultsmentioning

confidence: 99%

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Geest

Skirtach

Beer

et al. 2007

Macromol. Rapid Commun.

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Gold nanoparticles (AuNP) with carboxyl groups on their surface were used in combination with PAH for the layer‐by‐layer coating of CaCO3 microparticles, followed by the dissolution of the CaCO3 core. SEM, TEM, and confocal microscopy are used to characterize the hybrid nanoparticles/polyelectrolyte capsules. As the AuNP have carboxyl groups on their surface, their charge density is pH dependent; therefore, the capsules exhibit a pH‐dependent swelling and can be deconstructed both at low and high pH. By covalent cross‐linking of the carboxyl groups of the AuNP and the amino groups of the PAH, it is possible to suppress the pH‐responsive behavior. AuNP are used as activation centers using IR light and this ability is used to release encapsulated material from the nanoparticles/polyelectrolyte capsules as well as for the enhancement of detection and imaging of such capsules by Raman microspectrosopy.magnified image

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Section: Resultsmentioning

confidence: 99%

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Geest

Skirtach

Beer

et al. 2007

Macromol. Rapid Commun.

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“…Polyelectrolyte capsules with cross‐linked membrane, obtained via the layer‐by‐layer (LbL) deposition of polymers on colloidal template particles and subsequent removal of the core particles,47, 48 are attractive candidates for encapsulation of a diverse range of low molecular weight and macromolecules species49 allowing control over the capsule wall thickness, permeability, and stability 30. In order to preserve the spherical shape of hollow capsules under varying conditions mostly chemical cross‐linking30, 50, 51, 52, 53 was used.…”

Section: Introductionmentioning

confidence: 99%

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

et al. 2016

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Multifunctional and responsive hollow capsules are ideal candidates to establish highly sophisticated compartments mimicking cell membranes for controllable bio‐inspired functions. For this purpose pH and temperature dual‐responsive and photo‐cross‐linked hollow capsules, based on silica‐templated layer‐by‐layer approach by using poly(N‐isopropyl acrylamide)‐block‐polymethacrylate) and polyallylamine, have been prepared to use them for the subsequent and easily available post‐encapsulation process of protein‐like macromolecules at room temperature and pH 7.4 and their controllable release triggered by stimuli. The uptake and release properties of the hollow capsules for cargos are highly affected by changes in the external stimuli temperature (25, 37, or 45 °C) and internal stimuli pH of the phosphate‐containing buffer solution (5.5 or 7.4), by the degree of photo‐cross‐linking, and the size of cargo. The photo‐cross‐linked and dual stimuli‐responsive hollow capsules with different membrane permeability can be considered as attractive material for mimicking cell functions triggered by controllable uptake and release of different up to 11 nm sized biomolecules.

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“…However, there are many other polymers in use and it is also possible to produce biodegradable capsules made of polymers that can be digested/metabolized inside living cells, for example by proteases present in the lysosome [7,8]. There are two ways to load the capsules, the coprecipitation method, where the cargo is entrapped in the template and remains inside the capsules after removal of the template material, and the postloading method, where the permeability of the capsules can be controlled externally by variation of pH, salt concentration or temperature [9], and the cargo can be loaded into the empty capsules after the synthesis [10]. During the removal of the template core the capsules become much more porous due the osmotic pressure that arises by dissolving the core.…”

Section: Polyelectrolyte Multilayer Capsulesmentioning

confidence: 99%