“…2,3) The release properties of the matrix system were mathematically assessed by Higuchi,4) and matrix systems have often been used as a method of controlled drug release; however, it was considered that the mathematical analysis of the release process was insufficient, because the equation can not explain the entire release process. 1,5,6) In previous papers, the release process was divided into two stages to understand the entire release process and these were analyzed using a combination of the square-root time law and cube-root law equations.…”