Release from or through a Wax Matrix System. VI. Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet

An Update on Central Nervous System Stimulant Formulations in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

“…Before dissolution of the drug can begin, water must create a channel through the wax matrix layer. 29 This creates a constant release of methylphenidate, rather than a biphasic or triphasic release associated with the second-generation methylphenidates. Due to their delivery systems, these products should not be crushed, chewed, or divided.…”