Release characteristics of salmon calcitonin from dextran hydrogels for colon-specific delivery

Basan, Hasan; Gümüşderelı́oğlu, Menemşe; Orbey, M. Tevfik

doi:10.1016/j.ejpb.2006.07.008

Cited by 39 publications

(23 citation statements)

References 26 publications

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“…demonstrated the potential of dextran hydrogels for oral delivery by successfully releasing the anti-inflammatory agent, hydrocortisone [110]. Dextran hydrogels continue to be explored for delivery of peptide and protein drugs, such the peptide hormone salmon calcitonin [111]. …”

Section: Hydrogel Oral Delivery Systemsmentioning

confidence: 99%

Therapeutic applications of hydrogels in oral drug delivery

Sharpe

Daily

Horava

et al. 2014

Expert Opinion on Drug Delivery

278

193

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Introduction Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent potential as oral therapeutic systems due to inherent biocompatibility, diversity of both natural and synthetic material options and tunable properties. In particular, stimuli-responsive hydrogels exploit physiological changes along the intestinal tract to achieve site-specific, controlled release of protein, peptide and chemotherapeutic molecules for both local and systemic treatment applications. Areas covered This review provides a wide perspective on the therapeutic use of hydrogels in oral delivery systems. General features and advantages of hydrogels are addressed, with more considerable focus on stimuli-responsive systems that respond to pH or enzymatic changes in the gastrointestinal environment to achieve controlled drug release. Specific examples of therapeutics are given. Last, in vitro and in vivo methods to evaluate hydrogel performance are discussed. Expert opinion Hydrogels are excellent candidates for oral drug delivery, due to the number of adaptable parameters that enable controlled delivery of diverse therapeutic molecules. However, further work is required to more accurately simulate physiological conditions and enhance performance, which is important to achieve improved bioavailability and increase commercial interest.

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Section: Hydrogel Oral Delivery Systemsmentioning

confidence: 99%

Therapeutic applications of hydrogels in oral drug delivery

Sharpe

Daily

Horava

et al. 2014

Expert Opinion on Drug Delivery

278

193

View full text Add to dashboard Cite

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“…Their effect on the percentage of weight loss was greater than presence of dextranase enzyme. Since the percentage of weight loss of microspheres after degrading enzyme treatment due to the cleave dextran chains, by degrading glucosidic linkages, with enzymatic hydrolysis into the oligosaccharides and then weight loss occurs via diffusion of these oligosaccharides from the microspheres (Basan et al, 2007).…”

Section: In Vitro Enzymatic Degradationmentioning

confidence: 99%

Eudragit-coated dextran microspheres of 5-fluorouracil for site-specific delivery to colon

et al. 2014

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Objective of the present investigation was to prepare and evaluate the potential of enteric coated dextran microspheres for colon targeting of 5-fluorouracil (5-FU). Dextran microspheres were prepared by emulsification-crosslinking method and the formulation variables studied included different molecular weights of dextran, drug:polymer ratio, volume of crosslinking agent, stirring speed and time. Enteric coating (Eudragit S-100) of dextran microspheres was performed by oil-in-oil solvent evaporation method using different coat:core ratios (4:1 or 8:1). Uncoated and coated dextran microspheres were characterized by particle size, surface morphology, entrapment efficiency, DSC, in vitro drug release in the presence of dextranase and 2% rat cecal contents. The release study of 5-FU from coated dextran microspheres was pH dependent. No release was observed at acidic pH; however, the drug was released quickly where Eudragit starts solublizing there was continuous release of drug from the microspheres. Organ distribution study was suggested that coated dextran microspheres retard the release of drug in gastric and intestinal pH environment and released of drug from microspheres in colon due to the degradation of dextran by colonic enzymes.

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“…The typical approaches to produce hydrogels are essentially based on crosslinking by physical, ionic and/or covalent interactions [16]. Covalent crosslinking, in particular, is pursued through reaction of photo-crosslinkable moieties (such as acrylic groups), thiol-ene reactions, disulfide bond formation and all the different possible reactions involving complementary groups on the monomeric or polymeric precursor and, if needed, on a crosslinker [17][18][19][20][21][22][23]. These synthetic strategies can be applied either singularly or in a sequence, e.g.…”

Section: Introductionmentioning

confidence: 99%