Release Behavior of Amoxicillin from Glycol Chitosan Superporous Hydrogels

Abstract

Two kinds of amoxicillin-containing glycol chitosan superporous hydrogels, drug-dispersed and drug-conjugated, were synthesized as candidates for an efficient drug-delivery system to eradicate Helicobacter pylori. The swelling and drug-release patterns were investigated for application as drug carriers to cure gastric disease. Both the swelling capacity and swelling kinetics decreased with decreasing network mesh size associated with increasing cross-linking density. The drug-conjugated system showed much slower drug-release patterns than the drug-dispersed system, thus prolonging the drug-delivery effect. This difference in drug-release kinetics is attributed to the difference in the main release mechanism, diffusion for the drug-dispersed and hydrolysis for the drug-conjugated system.

Targeted Chemotherapy Based on Amplifying the Reactive Oxygen Species of Doxorubicin-Loaded Polyaspartamide-Encapsulated Iron Oxide Nanoparticles

“…In a normal cell environment with a pH of 7.4, the low Dox release was most likely produced by physical diffusion rather than chemical cleavage of the hydrazine linker. To further understand the process of drug release, the experimental data were fitted using the following simple semiempirical equation where M t and M o are the released amount (mass) of the drug over time t and the total amount of drug (mass) loaded at the beginning of the release process, respectively, k is a kinetic constant that characterizes the drug release rate of a carrier, and n is the exponent of kinetics which denotes the drug-releasing mechanism. , In the inset of Figure , the values of k and n fitted from the experimental data are listed. At pH = 7.4, n was close to 0.5, corresponding to the Fickian diffusion mechanism, in which drug release is regulated by the physical diffusion of the Dox associated with its concentration gradient.…”

Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives

“… 127 As another efficient delivery system for H. pylori therapeutic agents, hydrogels exhibit good biocompatibility, degradability, and controlled drug-release capacity. 128–130 Chitosan and its derivatives are often used as base materials to prepare hydrogels because of their antibacterial and adhesion properties with H. pylori . 129 , 131 , 132 For example, El-Mahrouk et al reported metronidazole-loaded pH-sensitive chitosan hydrogels for H. pylori eradication therapy.…”

Selective Release System for Antioxidative and Anti-Inflammatory Activities Using H2O2-Responsive Therapeutic Nanoparticles

“…Polymeric particles are used as drug delivery system or polymer-drug conjugated system for treatment . Most of polymeric drug delivery system entrap drugs physically and release in various environments.…”

“…10 Polymeric particles are used as drug delivery system or polymer-drug conjugated system for treatment. 11 Most of polymeric drug delivery system entrap drugs physically and release in various environments. On the other hand, conjugated drug and polymer systems are linked directly, and they can release drugs in specific pH or thermal conditions by the degradation of linkers.…”