Release and cellular acceptance of multiple drugs loaded silk fibroin particles

Shi, Pujiang; Goh, James Cho‐Hong

doi:10.1016/j.ijpharm.2011.08.051

Cited by 57 publications

(65 citation statements)

References 20 publications

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“…It was likely due to the electrostatic interaction, hydrophobic interactions, or diffusion of model drug. 10,23 According to Fick's law (J = -D dc/dx), higher loading capacity leads to a kinetic equilibrium state more quickly. The results in this report were consistent with the report of loading capacity of multidrug-loaded silk fibrillin described in Shi and Goh.…”

Section: Drug-loading and -Release Studymentioning

confidence: 99%

“…The results in this report were consistent with the report of loading capacity of multidrug-loaded silk fibrillin described in Shi and Goh. 10 The in vitro drug-release profiles of RhB from FBSA are shown in Figure 5. The profile showed that FBSA had a satisfactory controlled-release characteristic.…”

Section: Drug-loading and -Release Studymentioning

confidence: 99%

“…The soft surface made of natural protein had the advantage of constructing the carriers, because cells had the ability to sense the hardness of the culture surface. 10,27,28 To confirm that the sustained release of RhB from FBSA was better than that from the BSA NPs, we injected FBSARhB and BSA-NP-RhB into the right and left acoustic bullae of guinea pigs, respectively. Living images were taken at two time points: 0 and 48 hours.…”

Section: In Vivo Distribution Of Fbsa-rhbmentioning

confidence: 99%

“…This indicated that the addition of FBSA-H might have the function of providing nutrition and promoting cell proliferation due to the hydrophobic domain of such natural protein, just like silk fibroin particles. 10 FBSA-H had more advantages than other biomaterials, such as PLGA. However the nutrition properties of the proteins themselves on cell proliferation cannot compensate for the side effect of GA in the system, which explained the fact that most cells died in the FBSA-GA group ( Figure 6D).…”

mentioning

confidence: 99%

“…8 Many methods, such as film hydration, emulsion, template, microfluidic, mechanical stretching, and self-assembly can be used in the preparation of nonspherical particles. [9][10][11][12][13][14][15][16][17][18] It is of great importance to develop a simple method to prepare nonspherical particles with a high yield. 8 In this study, we demonstrated that bovine serum albumin (BSA) can form flower-shaped microparticles via modified desolvation fabricated with template and salting-out methods.…”

mentioning

confidence: 99%

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Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Yu¹,

Yu²,

Zhou

et al. 2014

IJN

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Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 μm to 100 μm, and most were 50–80 μm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment.

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Section: Drug-loading and -Release Studymentioning

confidence: 99%

Section: Drug-loading and -Release Studymentioning

confidence: 99%

Section: In Vivo Distribution Of Fbsa-rhbmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Yu¹,

Yu²,

Zhou

et al. 2014

IJN

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Efficacy of BMP‐2 Delivery from Natural Protein Based Polymeric Particles

Shi

Chen

Goh

2013

Adv Healthcare Materials

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A Moldable Putty Containing Silk Fibroin Yolk Shell Particles for Improved Hemostasis and Bone Repair

Saran

Shi

Ranjan

et al. 2014

Adv Healthcare Materials

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During minimally invasive orthopedic surgeries, surgical intervention is required at two stages; to attain hemostasis and subsequently to implant the bone graft or its substitute. There is an apparent need for a material which can simultaneously control bone bleeding and provide support for bone repair. In this work, a moldable putty, which can be applied to bone defects (usually irregular in shape), was developed to address this need. It comprises of a hemostatic factor thrombin, osteoinductive "yolk-shell" particles containing bone growth factor (BMP-2), and an osteoconductive component hydroxyapatite. The yolk shell particles allowed controlled release of BMP-2 and showed significantly enhanced osteogenic differentiation of C2C12 (mouse myoblast) cells as demonstrated by increased alkaline phosphatase (ALP) activity and relative gene expressions of osteogenic differentiation markers. These particles were assembled into a moldable putty by mixing them with hydroxyapatite and silk fibroin solution (binding agent) supplemented with thrombin. The putty showed non-cytotoxicity, hemostatic ability, sustained release of BMP-2 and induced increased mineralization in C2C12 cells. This putty, if applied to bone defects during surgeries, may help attain hemostasis and may enhance bone repair by providing sustained release of bone growth factors.

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Release and cellular acceptance of multiple drugs loaded silk fibroin particles

Cited by 57 publications

References 20 publications

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Efficacy of BMP‐2 Delivery from Natural Protein Based Polymeric Particles

A Moldable Putty Containing Silk Fibroin Yolk Shell Particles for Improved Hemostasis and Bone Repair

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