Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute

Okamura, Yosuke; Katsuno, Shunsuke; Suzuki, Hidenori; Maruyama, Hiroki; Handa, Makoto; Ikeda, Yasuo; Takeoka, Shinji

doi:10.1016/j.jconrel.2010.09.013

Cited by 30 publications

(45 citation statements)

References 29 publications

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“…Okamura et al (Okamura et al, 2010) developed a platelet substitute with hemostatic activity by conjugating the phospholipid vesicles (PC) with a dodecapeptide (HHLGGAKQAGDV, H12) to encapsulate ADP. They prepared H12-(ADP)-vesicles with various membrane flexibilities by freeze-drying, hydration with ADP, and then extrusion using membrane filters with different pore sizes.…”

Section: Particle-based Adenosine Carriersmentioning

confidence: 99%

“…They showed that, by controlling vesicle membrane deformability (membrane flexibility and lamellarity), the ATP release and subsequently the hemostatic property of H12-(ADP)-vesicles can be tuned (Fig. 1) (Okamura et al, 2010). …”

Section: Particle-based Adenosine Carriersmentioning

confidence: 99%

“…Schematic of ADP release from H12-(ADP)-vesicles with distinctive membrane characteristics designed by Okamura et al (a) Electron microscopic images of the H12-(ADP)-vesicles with different membrane flexibilities showing that the H12 molecules were bound to the vesicles, scale bars show 100 nm (Okamura et al, 2010). (b) ADP encapsulated vesicles (H12-(ADP)-vesicles) controlled their hemostatic abilities by tuning ADP release dependent on membrane properties.…”

Section: Figmentioning

confidence: 99%

“…(b) ADP encapsulated vesicles (H12-(ADP)-vesicles) controlled their hemostatic abilities by tuning ADP release dependent on membrane properties. It was reported that ADP release increased when either membrane flexibility increased or lamellarity decreased (Okamura et al, 2010), (c) Schematic structure of nanocarriers used for drug delivery (Orive et al, 2009). …”

Section: Figmentioning

confidence: 99%

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Adenosine-associated delivery systems

Kazemzadeh-Narbat¹,

Annabi²,

Tamayol³

et al. 2015

Journal of Drug Targeting

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Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat (arrhythmias), regulation of central nervous system (CNS) activity, and inhibiting seizural episodes can be carried out using adenosine. Despite the significant potential therapeutic impact of adenosine and its derivatives, the severe side effects caused by their systemic administration have significantly limited their clinical use. In addition, due to adenosine’s extremely short half-life in human blood (less than 10 s), there is an unmet need for sustained delivery systems to enhance efficacy and reduce side effects. In this paper, various adenosine delivery techniques, including encapsulation into biodegradable polymers, cell-based delivery, implantable biomaterials, and mechanical-based delivery systems, are critically reviewed and the existing challenges are highlighted.

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Section: Particle-based Adenosine Carriersmentioning

confidence: 99%

Section: Particle-based Adenosine Carriersmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

See 2 more Smart Citations

Adenosine-associated delivery systems

Kazemzadeh-Narbat¹,

Annabi²,

Tamayol³

et al. 2015

Journal of Drug Targeting

View full text Add to dashboard Cite

show abstract

“…In order to enhance the hemostatic effect, this PEGylated liposome‐based artificial platelet substitute bears a synthetic H12 on its surface, corresponding to the carboxy‐terminus of the fibrinogen γ‐chain, and the physiologic platelet agonist adenosine diphosphate (ADP) in the interior. In fact, it was reported that these modifications enable the liposomes to accumulate at the site of an injury in vivo by specifically binding to glycoprotein IIb/IIIa on activated platelet membranes, thus decreasing bleeding time in a dose‐dependent manner in both thrombocytopenic rat and rabbit models . Furthermore, we recently reported that H12‐(ADP)‐liposomes have an adequate circulation time in the blood to permit them to function as a platelet substitute in healthy animals and a thrombocytopenic model rat .…”

Section: Introductionmentioning

confidence: 96%

Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model

Taguchi

Hashimoto

Ogaki

et al. 2015

Journal of Pharmaceutical Sciences

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Adenosine diphosphate (ADP)-encapsulated liposomes coated with a fibrinogen γ-chain dodecapeptide [H12 (dodecapeptide ((400) HHLGGAKQAGDV(411) ))-(ADP)-liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (PEG). It has been reported that repeated injections of PEGylated liposomes induce an accelerated blood clearance (ABC) phenomenon, which involves a loss in the long-circulation half-life of the material when administered repeatedly to the same animals. The objective of this study was to determine whether the ABC phenomenon was induced by repeated injections of H12-(ADP)-liposome in healthy and anticancer drug-induced thrombocytopenia model rats. The findings show that the ABC phenomenon was induced by healthy rats that were repeatedly injected with H12-(ADP)-liposomes at the interval of 5 days at a dose of 10 mg lipids/kg. The ABC phenomenon involves the production of anti-H12-(ADP)-liposome immunoglobulin M (IgM) and complement activation. On the other hand, when thrombocytopenia model rats were repeatedly injected with H12-(ADP)-liposomes under the same conditions, no ABC phenomenon, nor was any suppression of anti-H12-(ADP)-liposome IgM-mediated complement activation observed. We thus conclude that the repeated injection of H12-(ADP)-liposome treatment in rat model with anticancer drug-induced thrombocytopenia did not induce the ABC phenomenon.

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A Natural Self‐Assembled Gel‐Sponge with Hierarchical Porous Structure for Rapid Hemostasis and Antibacterial

Zhang

Liu

et al. 2023

Adv Healthcare Materials

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Developing hemostatic agents with reliable biosafety and high efficiency has paramount clinical significance for saving lives. Herein, inspired from traditional Chinese medicine, a sponge (BC‐S) with hierarchical porous structure is proposed for the treatment of bleeding. The BC‐S is prepared by a simple self‐assembly method employing Bletilla Striata polysaccharide and quaternary amine alkaloids (QA) from Bletilla Striata and Coptidis Rhizoma. The ideal cation donor encapsulated in the helical structure of BSP enlarges the inter‐layer space of sponge by the action of electrostatic repulsion, forming wider channels which can accelerate the diversion speed of absorbed blood. Then, platelets and erythrocytes are trapped tightly in the reticular structure and extruded to deformation, activation. Subsequently, fibrin network forms and reinforces the internal multilayer mesh, blocks the outflow of blood. QA is released from the sponge skeleton mainly driven by a combination of surface erosion and potentially solution diffusion among pore to provide long‐term antibacterial activity. Benefiting from the well‐designed structure and the effective hemostatic mechanism, the BC‐S displays more excellent hemostatic performance in different models in vivo and in vitro compared with typical gelatin hemostatic sponge. This work is expected to boost the development of emerging hemostatic agents.

show abstract

Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute

Cited by 30 publications

References 29 publications

Adenosine-associated delivery systems

Adenosine-associated delivery systems

Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model

A Natural Self‐Assembled Gel‐Sponge with Hierarchical Porous Structure for Rapid Hemostasis and Antibacterial

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