Relaxometric Studies of Gd-Chelate Conjugated on the Surface of Differently Shaped Gold Nanoparticles

Fatehbasharzad, Parisa; Stefanìa, Rachele; Carrera, Carla; Hawala, Ivan; Castelli, Daniela Delli; Baroni, Simona; Colombo, Miriam; Prosperi, Davide; Aime, Silvio

doi:10.3390/nano10061115

Cited by 4 publications

(3 citation statements)

References 39 publications

(55 reference statements)

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“…As a result, 13 times higher relaxivity than that of the currently used clinical contrast agents was observed. Of the two NPs, PEG-Gd@CCNPs had the highest relaxivity, making them a promising candidate for MRI contrast agent [94]. PEG is a widely used polymer that offers stability and biocompatibility to gold nanoparticles.…”

Section: Consolidation Of Gold and Gadolinium Nanoparticles 41 Applic...mentioning

confidence: 99%

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Kouri

Polychronidou

Loukas

et al. 2023

JNT

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The multifactorial nature of cancer still classifies the disease as one of the leading causes of death worldwide. Modern medical sciences are following an interdisciplinary approach that has been fueled by the nanoscale revolution of the past years. The exploitation of high-Z materials, in combination with ionizing or non-ionizing radiation, promises to overcome restrictions in medical imaging and to augment the efficacy of current therapeutic modalities. Gold nanoparticles (AuNPs) have proven their value among the scientific community in various therapeutic and diagnostic techniques. However, the high level of multiparametric demands of AuNP experiments in combination with their biocompatibility and cytotoxicity levels remain crucial issues. Gadolinium NPs (GdNPs), have presented high biocompatibility, low cytotoxicity, and excellent hemocompatibility, and have been utilized in MRI-guided radiotherapy, photodynamic and photothermal therapy, etc. Τhe utilization of gadolinium bound to AuNPs may be a promising alternative that would reduce phenomena, such as toxicity, aggregation, etc., and could create a multimodal in vivo contrast and therapeutic agent. This review highlights multi-functionalization strategies against cancer where gold and gadolinium NPs are implicated. Their experimental applications and limitations of the past 5 years will be analyzed in the hope of enlightening the benefits and drawbacks of their proper combination.

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Section: Consolidation Of Gold and Gadolinium Nanoparticles 41 Applic...mentioning

confidence: 99%

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Kouri

Polychronidou

Loukas

et al. 2023

JNT

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“…The research proved that concave cube AuNPs are capable of producing brighter contrast compared with spherical ones. [132]…”

Section: Size and Shapementioning

confidence: 99%

Investigation of Bioimpacts of Metallic and Metallic Oxide Nanostructured Materials: Size, Shape, Chemical Composition, and Surface Functionality: A Review

Fatehbasharzad

Shamsi

2021

Part & Part Syst Charact

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Nanotechnology is set to impact a wide range of various fields, including medicine, materials technology, environmental sciences, and engineering/ manufacturing. Nanoparticles are categorized depending on their size, composition, shape, and surface functionality. Due to the excessive growth of nanostructured materials (NSMs) in production and industrial applications, human and environmental exposure to them and their possible toxicity issues are inevitable. The main objective of this review is to study NSMs, in particular metallic and metallic oxide nanoparticles, and properties that have a determinative role in their bioimpacts. Nevertheless, the main focus is to provide an overview of NSMs toxicology. Medical and environmental applications of the NSMs are discussed here. Also, key factors on the toxicity of the nanoparticles such as shape, size, chemical composition, and surface functionality are discussed. Finally, toxicity of the nanoparticles is going to be highlighted, and relevant studies are critically compared. This review gives a broad scientific view for improving the functional efficiency of nanomaterials while mitigating their possible adverse and unintended effects on biological systems.

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“…Research has shown that CAs with Gd as the magnetic center exhibit excellent T 1 /T 2 dual-mode imaging possibilities [ 4 ]. Recently, most dual-mode T 1 and T 2 MRI CAs have been designed as NPs with Gd shells [ 5 , 6 , 7 , 8 ]; in this study we propose a special 2D-structured Gd compound with remarkable T 1 and T 2 imaging functions.…”

Section: Introductionmentioning

confidence: 99%

Gd/Y Hydroxide Nanosheets as Highly Efficient T1/T2 MRI Contrast Agents

Xue

Xia

et al. 2020

Nanomaterials

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To develop highly efficient T1/T2 magnetic resonance imaging (MRI) contrast agents (CAs), Gd/Y hydroxide nanosheets were synthesized by a simple exfoliation method from layer compounds using sodium polyacrylate (PAA) as a dispersant and stabilizer. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) results revealed the excellent performance of monolayer nanosheets with thicknesses of up to 1.5 nm. The MRI results of the T1 and T2 relaxation times showed that all of the Gd/Y hydroxide nanosheets have high longitudinal and transverse relaxivities (r1 and r2). In particular, the 10% Gd-LRH nanosheets exhibited excellent MRI performance (r1 = 103 mM−1 s−1, r2 = 372 mM−1 s−1), which is rarely reported. Based on the relationship between the structure of 10% Gd-LRH nanosheets and their MRI performances, and the highly efficient MRI of spaced Gd atoms in the nanosheets, a special model to explain the outstanding MRI performance of the 10% Gd-LRH nanosheets is suggested. The cytotoxicity assessment of the 10% Gd-LRH nanosheets, evaluated by CCK-8 assays on HeLa cells, indicated no significant cytotoxicity. This study presents a significant advancement in 2D nanomaterial MRI CA research, with Gd-doped nanosheets positioned as highly efficient T1/T2 MRI CA candidates.

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Relaxometric Studies of Gd-Chelate Conjugated on the Surface of Differently Shaped Gold Nanoparticles

Cited by 4 publications

References 39 publications

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Investigation of Bioimpacts of Metallic and Metallic Oxide Nanostructured Materials: Size, Shape, Chemical Composition, and Surface Functionality: A Review

Gd/Y Hydroxide Nanosheets as Highly Efficient T1/T2 MRI Contrast Agents

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