Relaxivity of Gd‐EOB‐DTPA in the normal and biliary obstructed guinea pig

Shuter, Borys; Wang, S.-C.; Roche, James; Briggs, G. H.; Pope, J. H.

doi:10.1002/jmri.1880080415

Cited by 19 publications

(16 citation statements)

References 17 publications

(6 reference statements)

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“…The "real" relaxivity of Gd-DTPA in the kidney is even more complicated. In the vascular compartment, the Gd-DTPA relaxivity in full blood is different from that of heparinized plasma (17); furthermore, the hct changes between the large vessels and the capillaries (the "Fahraeus effect") (18). In the nephron the content of the urine changes markedly on its way from the glomeruli through the tubules to the excretion into the renal pelvis.…”

Section: Discussionmentioning

confidence: 99%

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Hackstein

Kooijman

Tomaselli

et al. 2005

Magnetic Resonance Imaging

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We determined the optimum gadolinium (Gd)-DTPA dose and time window for calculating the glomerular filtration rate (GFR) using contrast-enhanced (CE) dynamic MRI and the Patlak plot technique. Twelve adult volunteers with healthy kidneys were included in the study. As a reference method the GFR was measured by iopromide plasma clearance. A three-dimensional gradient-echo (GRE) sequence with a flip angle of 50°was used for MRI. Signal was measured using a body surface coil with four elements. Each volunteer was examined on four days using 2 mL, 4 mL, 8 mL, or 16 mL of Gd-DTPA 0.5 mmol/mL dissolved with sodium chloride (NaCl) 0.9% to a total of 60 mL. The injection rate was 1 mL/second. A Patlak plot was calculated from the kidney and aorta signals. The mean reference GFR was 133 mL/min (min-max, 116 -153 mL/min). The best correlation of GFR calculated from MRI data compared to the reference method was found in a time window 30 -90 seconds after aortic signal rise using 16 mL Gd-DTPA. Pearson's correlation coefficient was r ϭ 0.83, and the standard deviation (SD) from the line of regression was 10.5 mL/minute. We found a significantly lower average GFR(MR) using 16 mL Gd-DTPA compared to 4 mL and 2 mL in the late time window 60 -120 seconds post aortic rise. A dose of 16 mL Gd-DTPA was optimal for measuring GFR using dynamic MRI and the Patlak plot technique. The slope should be measured in a time window of 30 -90 seconds post aortic rise.

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Section: Discussionmentioning

confidence: 99%

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Hackstein

Kooijman

Tomaselli

et al. 2005

Magnetic Resonance Imaging

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“…Therefore, quantitative estimation of biological parameters requires a priori determination of the relaxivity of Gd in that tissue. This estimation is difficult to achieve experimentally since it requires the independent measure of Gd-DTPA concentration in the tissue by radioassay (25) or emission spectroscopy (21) techniques. Moreover, the Gd-DTPA is only present in the extracellular and plasma compartments.…”

Section: Discussionmentioning

confidence: 99%

Gd-DTPA relaxivity depends on macromolecular content

2000

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“…r 1 is the specific T1 relaxivity at physiological temperatures in plasma (4.1 L s −1 mmole −1 ) [24], [25].…”

Section: Methodsmentioning

confidence: 99%

Quantitative Estimation of Renal Function with Dynamic Contrast-Enhanced MRI Using a Modified Two-Compartment Model

et al. 2014

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ObjectiveTo establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Materials and MethodsA total of eight New Zealand white rabbits were included in DCE-MRI. The two-compartment model was modified with the impulse residue function in this study. First, the reliability of GFR measurement of the proposed model was compared with other published models in Monte Carlo simulation at different noise levels. Then, functional parameters were estimated in six healthy rabbits to test the feasibility of the new model. Moreover, in order to investigate its validity of GFR estimation, two rabbits underwent acute ischemia surgical procedure in unilateral kidney before DCE-MRI, and pixel-wise measurements were implemented to detect the cortical GFR alterations between normal and abnormal kidneys.ResultsThe lowest variability of GFR and RPF measurements were found in the proposed model in the comparison. Mean GFR was 3.03±1.1 ml/min and mean RPF was 2.64±0.5 ml/g/min in normal animals, which were in good agreement with the published values. Moreover, large GFR decline was found in dysfunction kidneys comparing to the contralateral control group.ConclusionResults in our study demonstrate that measurement of renal kinetic parameters based on the proposed model is feasible and it has the ability to discriminate GFR changes in healthy and diseased kidneys.

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Relaxivity of Gd‐EOB‐DTPA in the normal and biliary obstructed guinea pig

Cited by 19 publications

References 17 publications

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Glomerular filtration rate measured using the Patlak plot technique and contrast‐enhanced dynamic MRI with different amounts of gadolinium‐DTPA

Gd-DTPA relaxivity depends on macromolecular content

Quantitative Estimation of Renal Function with Dynamic Contrast-Enhanced MRI Using a Modified Two-Compartment Model

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