Relaxivity of Gd‐Based MRI Contrast Agents in Crosslinked Hyaluronic Acid as a Model for Tissues

Fragai, Marco; Ravera, Enrico; Tedoldi, Fabio; Luchinat, Claudio; Parigi, Giacomo

doi:10.1002/cphc.201900587

Cited by 16 publications

(12 citation statements)

References 55 publications

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“…This enhancement increases with increasing the reorientation time of the macromolecule, and for reorientation times of microseconds or larger it largely exceeds the paramagnetic enhancement calculated with the Solomon equation and 100 protons at the same distance from the gadolinium ion and with the same exchange rate. Of note, for so large reorientation times (and lack of any internal mobility), the paramagnetic enhancement can almost reach the values achieved at the same fields by small complexes with a water molecule coordinated to the gadolinium ion and used in MRI (as Gd-DOTA or Gd-DTPA) (Anelli et al, 2000;Caravan et al, 1999;Fragai et al, 2019). Fig.…”

Section: Discussion Open Accessmentioning

confidence: 90%

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Bellomo¹,

Ravera²,

Calderone³

et al. 2020

Preprint

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Abstract. Cross relaxation terms in paramagnetic systems that reorient rigidly with slow tumbling times can increase the effective longitudinal relaxation rates of protons of more than one order of magnitude. This is evaluated by simulating the time evolution of the nuclear magnetization using a complete relaxation matrix approach. The calculations show that the Solomon dependence of the relaxation rates on the metal-proton distance (as r−6) can be incorrect for protons farther than 15 Å from the metal, and thus can originate sizable errors in R1-derived distance restraints used, for instance, for protein structure determination. Furthermore, the chemical exchange of these protons with bulk water protons can enhance the relaxation rate of the solvent protons by far more than expected from the Solomon equation. Therefore, it may contribute significantly to the water proton relaxation rates measured at MRI magnetic fields in the presence of slow-rotating nanoparticles containing paramagnetic ions and a large number of exchangeable surface protons.

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Section: Discussion Open Accessmentioning

confidence: 90%

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Bellomo¹,

Ravera²,

Calderone³

et al. 2020

Preprint

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“…To characterize the coordination of the lanthanides in T1 , Fast Field Cycling (FFC) relaxometry experiments were performed . The 1 H nuclear magnetic relaxation dispersion (NMRD) profiles of the [ T1 (Gd)] complex in water solution at 10, 25 and 37 °C are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

The Photocatalyzed Thiol‐ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins

et al. 2020

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Paramagnetic restraints have been used in biomolecular NMR for the last three decades to elucidate and refine biomolecular structures, but also to characterize protein-ligand interactions. A common technique to generate such restraints in proteins, which do not naturally contain a (paramagnetic) metal, consists in the attachment to the protein of a lanthanide-binding-tag (LBT). In order to design such LBTs, it is important to consider the efficiency and stability of the conjugation, the geometry of the complex (conformational exchanges and coordination) and the chemical inertness of the ligand. Here we describe a photocatalyzed thiol-ene reaction for the cysteine-selective paramagnetic tagging of proteins. As a model, we designed an LBT with a vinyl-pyridine moiety which was used to attach our tag to the protein GB1 in fast and irreversible fashion. Our tag T1 yields magnetic susceptibility tensors of significant size with different lanthanides and has been characterized using NMR and relaxometry measurements.

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“…In addition to HMONs, some metal hollow nanostructures with strong NIR absorption show high photothermal conversion efficiency and excellent photoacoustic imaging (PA) ability due to the local plasmon resonance effect [91][92][93][94][95][96]. In 2019, Liang and co-workers synthesized a temperature-sensitive polymer modified Pt-CuS hollow structure [97].…”

Section: Inorganic Nanomaterials As the Nano Carriers Of Molecular Somentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

et al. 2020

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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Relaxivity of Gd‐Based MRI Contrast Agents in Crosslinked Hyaluronic Acid as a Model for Tissues

Cited by 16 publications

References 55 publications

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

The Photocatalyzed Thiol‐ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins

Recent advances in nanomaterials for sonodynamic therapy

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