Relaxivity and toxicological properties of manganese oxide nanoparticles for MRI applications

Hsu, Benedict You Wei; Kirby, Georgia; Tan, Aaron; Seifalian, Alexander M.; Li, Xu; Wang, John

doi:10.1039/c6ra04421b

Cited by 44 publications

(37 citation statements)

References 61 publications

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“…See Fig. 7 The viability of human fibroblast cells HFFF2 treated with different concentration of CaLs and MnO-CaLs NPs for 24 h measured by MTT assay.40504 | RSC Adv., 2019,9,[40498][40499][40500][40501][40502][40503][40504][40505][40506] This journal is…”

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confidence: 99%

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Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

2019

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A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T 1 contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm were prepared by thermal decomposition of manganese(II)acetylacetonate in the presence of oleic acid as a surfactant. The characteristics of the synthesized nanoparticles, cytotoxicity assay and in vitro MRI properties were investigated in detail. Results showed that calcium lignosulfonate has a great influence on the colloidal stability and biocompatibility of MnO nanoparticles in water. Furthermore, this coating agent ensures abundant exposure of external Mn ion with protons of water, which endows the nanoparticles with a longitudinal molar relaxivity (r 1 ) of 4.62 mM À1 s À1 . An efficient contrast enhancement effect was observed in the study of MRI investigations. † Electronic supplementary information (ESI) available: Zeta potential of MnO-CaLs NPs; solid-state UV absorption spectra of MnO-OA NPs, CaLs and MnO-CaLs NPs; signal intensity against TR in T 1 -weighted MRI images and signal intensity against TE in T 2 -weighted MRI images. See Fig. 7 The viability of human fibroblast cells HFFF2 treated with different concentration of CaLs and MnO-CaLs NPs for 24 h measured by MTT assay.40504 | RSC Adv., 2019,9,[40498][40499][40500][40501][40502][40503][40504][40505][40506] This journal is

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confidence: 99%

“…40504 | RSC Adv., 2019,9,[40498][40499][40500][40501][40502][40503][40504][40505][40506] This journal is…”

mentioning

confidence: 99%

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

2019

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“…[17][18][19][20] Other manganese nanostructures such as Mn 3 O 4 (manganese(II, III) oxide)h ave also been proposed and tested as classic T 1 MRI CAs. [21,22] These kind of classic T 1 contrast agents are out of the scope of this review, but for more information the readerc an refer to references [11,[23][24][25][26].…”

Section: Manganese In Mrimentioning

confidence: 99%

“…Although ap roper discussion on these parameters is out of the scope of this minireview,t he following references can give the readera ni nsight into such matters. [10,11] Potential toxic effects from Mn-based nanostructures can arise from several mechanismsi ncluding the productiono fr eactive oxygen speciesa nd an excessive accumulationo fM n 2 + ions owing to nanoparticle (NP) degradation. [11] Chen et al [10] reported an increase in apoptosis in the lungs induced by the systemic administration of 15 nm MnO NPs.…”

Section: Introductionmentioning

confidence: 99%

“…[10,11] Potential toxic effects from Mn-based nanostructures can arise from several mechanismsi ncluding the productiono fr eactive oxygen speciesa nd an excessive accumulationo fM n 2 + ions owing to nanoparticle (NP) degradation. [11] Chen et al [10] reported an increase in apoptosis in the lungs induced by the systemic administration of 15 nm MnO NPs. But furthers ystematic studies are needed to elucidate the safety profile of Mn-based nanostructures.…”

Section: Introductionmentioning

confidence: 99%

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Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

García‐Hevia

Bañobre‐López

Gallo

2018

Chemistry A European J

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Manganese-based nanostructured contrast agents (CAs) entered the field of medical diagnosis through magnetic resonance imaging (MRI) some years ago. Although some of these Mn-based CAs behave as classic T contrast enhancers in the same way as clinical Gd-based molecules do, a new type of Mn nanomaterials have been developed to improve MRI sensitivity and potentially gather new functional information from tissues by using traditional T contrast enhanced MRI. These nanomaterials have been designed to respond to biological environments, mainly to pH and redox potential variations. In many cases, the differences in signal generation in these responsive Mn-based nanostructures come from intrinsic changes in the magnetic properties of Mn cations depending on their oxidation state. In other cases, no changes in the nature of Mn take place, but rather the nanomaterial as a whole responds to the change in the environment through different mechanisms, including changes in integrity and hydration state. This review focusses on the chemistry and MR performance of these responsive Mn-based nanomaterials.

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Relaxivity and toxicological properties of manganese oxide nanoparticles for MRI applications

Cited by 44 publications

References 61 publications

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

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Relaxivity and toxicological properties of manganese oxide nanoparticles for MRI applications

Cited by 44 publications

References 61 publications

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T1 MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T1 MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

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Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity