“…Thus, mature Ppe-RGP is produced from its precursor protein by elimination of the signal peptide and C-peptide and formation of intra-chain and inter-chain disulfide bridges within and between the A-and Bchains. Orthologs of PpeRGP have also been identified in other starfish, including species belonging to the orders Valvatida, Forcipulatida, Paxillosida, Platyasteroidea, Spinulosida, and Valatida (Mita, 2013(Mita, , 2016Semmens et al, 2016;Lin et al, 2017;Smith et al, 2017;Mita et al, 2015Mita et al, , 2020aMita et al, , 2022Katayama and Mita, 2023;Mita, 2023).…”