Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers

Aragón-Herrera, Alana; Couselo‐Seijas, Marinela; Feijóo‐Bandín, Sandra; Anido-Varela, Laura; Moraña-Fernández, Sandra; Tarazón, Estefanía; Roselló‐Lletí, Esther; Portolés, Manuel; Martínez‐Sande, José Luis; García‐Seara, Javier; Álvarez, Ezequiel; González-Juanàtey, José Ramón; Rodríguez‐Mañero, Moisés; Eiras, Sonia; Lago, Francisca

doi:10.1038/s41598-022-26836-1

Cited by 6 publications

(4 citation statements)

References 72 publications

(126 reference statements)

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“…Elevated levels of relaxin-2 are associated with reduced expression of inflammatory markers, hydrogen peroxide concentration, inflammation, and OS genes. In vitro, treatment with relaxin-2 has demonstrated its ability to inhibit the migration of atrial heart fibroblasts and reduce the expression of profibrotic molecules [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

Menezes Júnior,

França-e-Silva,

Oliveira

et al. 2023

IJMS

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Atrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct relationship exists between AF and altered mitochondrial activity resulting from membrane potential loss, contractile dysfunction, or decreased ATP levels. This review aimed to elucidate the role of mitochondrial oxidative mechanisms in AF pathophysiology, the impact of mitochondrial oxidative stress on AF initiation and perpetuation, and current therapies. This review followed the Preferred Reporting Items for Systematic Reviews and the Meta-Analysis Extension for Scoping Reviews. PubMed, Excerpta Medica Database, and Scopus were explored until June 2023 using “MESH terms”. Bibliographic references to relevant papers were also included. Oxidative stress is an imbalance that causes cellular damage from excessive oxidation, resulting in conditions such as AF. An imbalance in reactive oxygen species production and elimination can cause mitochondrial damage, cellular apoptosis, and cardiovascular diseases. Oxidative stress and inflammation are intrinsically linked, and inflammatory pathways are highly correlated with the occurrence of AF. AF is an intricate cardiac condition that requires innovative therapeutic approaches. The involvement of mitochondrial oxidative stress in the pathophysiology of AF introduces novel strategies for clinical treatment.

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Section: Resultsmentioning

confidence: 99%

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

Menezes Júnior,

França-e-Silva,

Oliveira

et al. 2023

IJMS

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“…Previous studies have linked inflammation and oxidative stress to the pathophysiology of AF. 23 In the KEGG analyses, both glycolic acid and l ‐serine are linked with the carbon metabolism and glyoxylate and dicarboxylate metabolic pathways that are associated with AF (Figure 5 ). Glycolic acid is highly associated with xanthine, which is related to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics and Biomarkers for Paroxysmal and Persistent Atrial Fibrillation

Zhang,

Lin,

et al. 2024

JAHA

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Background Atrial fibrillation (AF) is the most common type of arrhythmia worldwide and is associated with serious complications. This study investigated the metabolic biomarkers associated with AF and the differences in metabolomics and associated metabolic biomarkers between paroxysmal AF (AFPA) and persistent AF. Methods and Results Plasma samples were prospectively collected from patients with AF and patients in sinus rhythm with negative coronary angiography. The patients were divided into 3 groups: AFPA, persistent AF, and sinus rhythm (N=54). Metabolomics (n=36) using ultra‐high‐performance liquid chromatography mass spectrometry was used to detect differential metabolites that were validated in a new cohort (n=18). The validated metabolites from the validation phase were further analyzed by receiver operating characteristic. Among the 36 differential metabolites detected by omics assay, 4 were successfully validated with area under the curve >0.8 ( P <0.05). Bioinformatics analysis confirmed the enrichment pathways of unsaturated fatty acid biosynthesis, glyoxylate and dicarboxylate metabolism, and carbon metabolism. Arachidonic acid was a potential biomarker of AFPA, glycolic acid and L‐serine were biomarkers of AFPA and persistent AF, and palmitelaidic acid was a biomarker of AFPA. Conclusions In this metabolomics study, we detected 36 differential metabolites in AF, and 4 were validated with high sensitivity and specificity. These differential metabolites are potential biomarkers for diagnosis and monitoring of disease course. This study therefore provides new insights into the precision diagnosis and management of AF.

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“…A class of peptide hormone/neuromodulators known as relaxins (RLNs) can control various physiological functions, including brain function and reproduction [ 16 ]. In pathological conditions like AF (atrial fibrillation) and cardiac failure, relaxin-2 has several beneficial cardiovascular benefits, although the exact processes by which it works are still poorly known [ 17 ]. Relaxin-2 plays a crucial function in many malignancies, as evidenced by the pro- and antitumor effects observed in various malignant tumors.…”

Section: Reviewmentioning

confidence: 99%

Predisposing and Overall Effects of Reproductive Hormones on Breast Cancer: A Review

Sarda,

Jogdand

2023

Cureus

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Cancer, the second leading cause of mortality worldwide, has been the subject of extensive and quickly changing scientific study and practice. Cancer remains a mystery despite the enormous effort put into understanding the genesis of cancerous cells, the development of malignant tissues, and the process by which they propagate and recur. Cells from humans that have been recruited by cancer and, to some extent, changed into pathogenic organisms or the foundation of tumors serve as agents of destruction. Understanding cancers leads to challenging philosophical issues since they undermine and use multicellular organization processes. Cancer metastasizing cells adopt new phenotypes while discarding previous behaviors. The absence of comprehensive knowledge of this has hampered the development of therapeutics for metastatic illness. For systems-level experimental and computational metastasis modeling, integrating these complex and interconnected features continues to be a problem because metastasis has typically been studied in separate physiological compartments. Lung, breast, and prostate cancers accounted for the bulk of the 18 million new cases of cancer that were diagnosed in 2018. The most frequent cancer in women is breast cancer. Animal experimentation plays a significant role in primary and translational breast cancer research. In theory, such breast cancer models should be comparable to breast cancer in humans in terms of tumor etiology, biological behavior, pathology, and treatment response.

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Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers

Cited by 6 publications

References 72 publications

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

Metabolomics and Biomarkers for Paroxysmal and Persistent Atrial Fibrillation

Predisposing and Overall Effects of Reproductive Hormones on Breast Cancer: A Review

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