We study the prethermalization and thermalization dynamics of local observables in weakly perturbed nonintegrable systems, with Hamiltonians of the form Ĥ0 + g V , where Ĥ0 is nonintegrable and g V is a perturbation. We explore the dynamics of far from equilibrium initial states in the thermodynamic limit using a numerical linked cluster expansion (NLCE), and in finite systems with periodic boundaries using exact diagonalization. We argue that generic observables exhibit a twostep relaxation process, with a fast prethermal dynamics followed by a slow thermalizing one, only if the perturbation breaks a conserved quantity of Ĥ0 and if the value of the conserved quantity in the initial state is O(1) different from the one after thermalization. We show that the slow thermalizing dynamics is characterized by a rate ∝ g 2 , which can be accurately determined using a Fermi golden rule (FGR) equation.