Relaxation mechanisms, bonding, and molecular reorientation in CpRe(CO)3

[Fe(L-cysteinate)(2)(CO)(2)](2-) is a CO releasing molecule which has low cytotoxicity to RAW264.7 macrophages. It provides an example of CO binding using ligands available to ion channels which use CO as a signalling molecule in the absence of heme. Previous work has shown that this compound consists of five isomers and it was proposed that the two isomers with trans-dicarbonyls are dominant. In this work the isomers are re-assigned and shown to be capable of releasing CO, albeit too slowly to act as a signalling receptor. It is shown that by linking the two L-cysteines together to form [Fe(SCH(2)CH{CO(2)H}NHCH(2))(2)(CO)(2)], only one isomer is isolated.

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Relaxation mechanisms, bonding, and molecular reorientation in CpRe(CO)3

Cited by 4 publications

References 64 publications

Oxygen-17 NMR spectroscopy: Basic principles and applications (Part I)

Oxygen-17 NMR spectroscopy: Basic principles and applications (Part I)

Oxygen-17 NMR spectroscopy: Basic principles and applications (part II)

A re-investigation of [Fe(l-cysteinate)2(CO)2]2−: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

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