Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T

Loi, Lisa; Zimmermann, F; Goerke, Steffen; Korzowski, Andreas; Meißner, Jan; Deike-Hofmann, Katerina; Stieber, Anne; Bachert, Peter; Ladd, Mark E.; Bickelhaupt, Sebastian; Schott, Sarah; Paech, Daniel

doi:10.1016/j.ejrad.2020.109068

Cited by 23 publications

(33 citation statements)

References 46 publications

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“…We used fat saturation pulses immediately before the image acquisition sequence because the presence of fat signals is known to reduce amide proton transfer-type MTR asym measurements (20,22,23,30). Our acquisition method was used to image only a single side of the breast with a small field of view, resulting in a more homogeneous B 0 field that was generally within 60.5 ppm, thereby ensuring more effective fat suppression.…”

Section: Mr Image Acquisitionmentioning

confidence: 99%

“…APT W CEST MRI has been investigated for tumor diagnosis as well as treatment assessment, primarily for brain cancer studies (13,17). APT W CEST MRI has also been developed for breast cancer studies (17)(18)(19)(20)(21)(22)(23)(24)(25), including a few studies that have investigated breast cancer treatment response to NAST (18,24,25). These studies have typically evaluated a variety of breast cancer types in the same study, have tested saturation powers ranging from 0.5 to 2.0 µT, and have used different analysis methods.…”

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confidence: 99%

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Assessment of Early Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer Using Amide Proton Transfer–weighted Chemical Exchange Saturation Transfer MRI: A Pilot Study

Zhang¹,

Rauch²,

Adrada³

et al. 2021

Radiology: Imaging Cancer

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T riple-negative breast cancer (TNBC) accounts for about 10%-20% of all breast cancers, and it is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (1). Compared with other types of breast cancer, TNBC is considered more aggressive, with a higher recurrence rate and decreased overall survival (1,2). Within the TNBC group, pathologic complete response (pCR) to neoadjuvant systemic therapy (NAST) is strongly correlated with improved disease-free survival and overall survival (3). Because only about 20%-50% of participants with TNBC will achieve pCR, early assessment of the treatment response is beneficial (4-6). For example, participants with predicted non-pCR may be directed toward more aggressive or potentially more effective novel therapies at an early stage.The effectiveness of NAST is most commonly assessed by the change in tumor size based on conventional breast imaging (eg, mammography, US) and clinical examination (7). The appropriateness criteria of the American

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Section: Mr Image Acquisitionmentioning

confidence: 99%

mentioning

confidence: 99%

Assessment of Early Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer Using Amide Proton Transfer–weighted Chemical Exchange Saturation Transfer MRI: A Pilot Study

Zhang¹,

Rauch²,

Adrada³

et al. 2021

Radiology: Imaging Cancer

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“…However, despite the high potential of mpMRI for breast cancer screening, large clinical trials are still missing owing to the lack of harmonized protocols. In the future, new image contrasts might further improve screening methods with early studies indicating the potential of chemical exchange saturation transfer and hyperpolarized Carbon‐13 MRI to identify suspicious lesions in prostate and breast cancer 38‐40 …”

Section: Secondary Prevention: Toward Personalized Risk‐adapted Screening Programsmentioning

confidence: 99%

Solving problems is smart, preventing them is wise: Lessons learned from the 2nd International DKFZ Conference on Cancer Prevention

Gillmann

Pajor

Ramadori

et al. 2021

Intl Journal of Cancer

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The 2nd International DKFZ Conference on Cancer Prevention (CCP2020) organized by the German Cancer Research Center (DKFZ) was held as a virtual event on 17-18 September 2020. The event gathered experts on cancer prevention from around the world with the aim of generating a stimulating interchange of opinions between clinicians and basic researchers working in the field. The talks and posters of the conference fueled exciting discussions and debates about the state of the art of cancer prevention and provided a comprehensive outlook on the many aspects of the field.The program was divided into three main sessions, illustrating the most recent methodological approaches and interventions in primary, secondary and tertiary prevention, enriched by introductory lectures depicting the most relevant aspects of each session. The key concepts covered in this meeting were risk factors, early detection, improving life after cancer, cancer prevention in Europe and personalized prevention.

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“…Investigators in recent human studies have also reported preliminary APT findings in the breast (16)(17)(18)(19), cervices (20,21), prostate (22,23), and chest (8), demonstrating that it is an effective tool for tumor detection and characterization. APT values were higher in cancers than in normal surrounding tissues (22) and benign tumors (8).…”

Section: Introductionmentioning

confidence: 96%

Feasibility evaluation of amide proton transfer-weighted imaging in the parotid glands: a strategy to recognize artifacts and measure APT value

Chen

Wang

et al. 2021

Quant Imaging Med Surg

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Background: The feasibility and image quality of three-dimensional (3D) amide proton transfer (APT)weighted (APTw) in parotid tumor lesions have not been well established in previous studies. This study aimed to evaluate the utility of APT imaging in parotid lesions and glands.Methods: Patients with parotid lesions received 3D turbo spin echo (TSE) APTw on a 3.0T scanner. Two radiologists, who were blinded to the clinical data, independently evaluated the APTw image quality using 4-point Likert scales (1= poor, 4= excellent) in terms of integrity and hyperintensity artifacts. An image quality selection protocol was built based on the two scores. Evaluable images (integrity score >1) and trustable images (integrity score >3 and hyperintensity artifacts score >2) were then enrolled for APTw value comparison between parotid lesions and glands.Results: Forty consecutive patients were included in this study. Four patients were excluded due to severe motion (n=3) or dental (n=1) artifacts, and 36 patients received the APT sequence. Among these, more parotid tumor lesions (34/36, 94.4%) than normal parotid glands (23/31, 74.2%) revealed excellent integrity scores (score =4) (P=0.034). Most parotid tumor lesions (24/34, 70.6%) and glands (16/28, 57.1%) revealed no or little hyperintensity artifacts for diagnosis (scores 3 and 4). APT values of parotid lesions and glands in the evaluable groups were 2.11%±1.15% and 1.60%±1.56%, respectively, and the difference was not significant (P=0.197). APT values of parotid lesions and glands in the trustable groups were 1.99%±1.18% and 1.03%±1.09%, respectively, and the difference was statistically significant (P=0.018).Conclusions: 3D APTw could be used to differentiate parotid tumors and normal parotid glands; however, the technology still needs to be improved to remove artifacts. In our study, most APTw images of tumor lesions in parotid glands had acceptable image quality, and these APTw images are feasible for diagnostic use.

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Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T

Cited by 23 publications

References 46 publications

Assessment of Early Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer Using Amide Proton Transfer–weighted Chemical Exchange Saturation Transfer MRI: A Pilot Study

Assessment of Early Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer Using Amide Proton Transfer–weighted Chemical Exchange Saturation Transfer MRI: A Pilot Study

Solving problems is smart, preventing them is wise: Lessons learned from the 2nd International DKFZ Conference on Cancer Prevention

Feasibility evaluation of amide proton transfer-weighted imaging in the parotid glands: a strategy to recognize artifacts and measure APT value

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