Relaxant effect of the prostacyclin analogue iloprost on isolated human radial artery: An approach for the reversal of graft spasm

Engin, Ersoy; Yildirim, F. İlkay Alp; Durman, Deniz Kaleli; Göksedef, Deniz; Teskìn, Önder; Balkanay, Ozan Onur; İpek, Gökhan; Doğan, B. Sönmez Uydeş

doi:10.1016/j.prostaglandins.2017.10.003

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…The results of 19 studies by Engin E et al were analyzed revealed that RAS occurred in 15.2% of patients. 9 These outcomes were a little better than the others that were given. Additionally, he claimed that using 1.25-5 mg of verapamil along with 100-200 g of nitroglycerine could reduce RAS by up to 4.1%.…”

Section: Introductionmentioning

confidence: 91%

Effectiveness of Calcium Channel Blockers and Nitrates in Inhibition of Spasm of Radial Artery during Coronary Angiography

Arfat¹,

Faraz²,

Nazim³

et al. 2023

PJMHS

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Background: The most common issue with transradial cardiac catheterization is radial artery vasospasm. The patient experiences pain and discomfort as a result, the procedure is prolonged, and the interventionist may even be unable to continue. Aim: The aim of the study is to determine the effectiveness of Verapamil, a calcium channel blocker and nitrate, when used together to prevent radial artery spasm during coronary angiographies. Methods: This case control study was held in the Cardiology department of Qazi Hussain Ahmed Medical Complex, Nowshera and Peoples University of Medical and Health Sciences for Women PUMHSW (SBA) Nawabshah for six-months duration from July 2021 to December 2021 including 120 cardiac patients undergoing coronary angiography. The patients were selected by non-probability sampling technique. Patients who were enrolled in the study provided written informed consent. Two groups of patients—control (60) and experimental—were formed (60). Heparin/nitrate was administered to one group and labelled as a control group, while heparin/nitrates/verapamil (a calcium channel blocker) was administered to the other group considered as an experimental group. During the angiography procedure, the radial spasm, discomfort, and catheter resistance were assessed in both groups. A predesigned questionnaire was used to collect all other demographic data and patient’s history. SPSS version 23.0 was used to collect and analyse the data. Results: It was found that 68.3% of cardiac patients were over 50 years old, 41.7% of patients were female, and 58.3% of patients were male. Verapamil, a calcium channel blocker, and nitrate did not significantly affect radial spasm, according to this study with a p value of 0.762. According to the study, there was no obvious difference noted in radial spasm, outcome, discomfort, catheter resistance, or procedure time when cases and controls were compared for various variables. However, the test group have a 100% success rate of the procedure compared to the control group's 95%. Conclusion: Verapamil, a calcium channel blocker when combined with nitrate did not significantly reduce radial spasm during coronary angiography. The theory that calcium channel blockers could prevent radial artery spasm during angiography was nullified. It is best to avoid the financial burden that comes with using calcium channel blockers and nitrate during coronary angiography. Combining nitrate and calcium channel blocker (Verapamil) has no additional advantages. Keywords: Angiography, catheterization, calcium channel blocker, radial spasm, nitrate, and verapamil are some of the related terms.

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Section: Introductionmentioning

confidence: 91%

Effectiveness of Calcium Channel Blockers and Nitrates in Inhibition of Spasm of Radial Artery during Coronary Angiography

Arfat¹,

Faraz²,

Nazim³

et al. 2023

PJMHS

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“…Although there was a previous study about the topical iloprost effects on isolated human radial artery [35] , to our knowledge, there is no in-vivo prospective study yet to reveal the effects of topical iloprost administration on IMA blood flow compared to papaverine. In this study, we aimed to compare the topical effects of iloprost with papaverine as a primary objective and to see its effects on the cellular level as a secondary objective.…”

Section: Iloprostmentioning

confidence: 97%

Comparison of iloprost and papaverine in topical vasodilation of internal mammary artery in coronary artery bypass grafting: A prospective randomized trial

Yalvaç¹

2020

Haydarpasa Numune Med J

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Introduction: Internal mammary artery (IMA) graft is a commonly used coronary artery bypass conduit due to its high longterm patency rates. IMA may have a perioperative arterial spasm problem. Papaverine, an opium alkaloid, is commonly used in vasospasm, especially for IMA. Iloprost, a synthetic prostacyclin analogue, could be an alternative to papaverine. In this study, we compared the effects of topical iloprost and papaverine concerning the prevention of IMA vasospasm. Methods: Between May-August 2009, 40 consecutive patients who underwent coronary artery bypass grafting using IMA graft were included in this prospective study. Patients were divided into two groups to be treated with topical vasodilators as iloprost and papaverine groups. The free blood flow of IMA was measured before and after the topical vasodilators were applied. These results were evaluated together with concurrently measured mean arterial pressures. Histopathologic examination was performed with the distal part of IMA and scored according to the desquamation rate. Results: Preoperative and haemodynamic parameters between the two groups were similar. With both vasodilator agents, the amount of IMA blood flow was increased in a similar ratio as well. Analysis of this increase was assessed by dividing the blood flow by the mean arterial blood pressure value. Iloprost group had similar vasodilation response when compared with the response of the papaverine group. There was more desquamation in the papaverine group at a significant level. There was no significant difference between the two groups in terms of postoperative mortality and complications. Discussion and Conclusion: We concluded that iloprost could be an alternative for papaverine with similar vasodilation response and lower level of endothelial damage.

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Release of 6-nitrodopamine from human popliteal artery and vein

et al. 2023

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Relaxant effect of the prostacyclin analogue iloprost on isolated human radial artery: An approach for the reversal of graft spasm

Cited by 4 publications

References 46 publications

Effectiveness of Calcium Channel Blockers and Nitrates in Inhibition of Spasm of Radial Artery during Coronary Angiography

Effectiveness of Calcium Channel Blockers and Nitrates in Inhibition of Spasm of Radial Artery during Coronary Angiography

Comparison of iloprost and papaverine in topical vasodilation of internal mammary artery in coronary artery bypass grafting: A prospective randomized trial

Release of 6-nitrodopamine from human popliteal artery and vein

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