1987
DOI: 10.1111/j.1476-5381.1987.tb11201.x
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Relaxant effect of the H2‐receptor antagonist oxmetidine on guinea‐pig and human airways

Abstract: 1The effects of three different H2-receptor antagonists (cimetidine, ranitidine and oxmetidine) were tested on isolated preparations of guinea-pig trachea and human bronchus against contractions induced by acetylcholine, histamine and potassium chloride (KCl). In addition, their influence on calcium concentration-response curves in guinea-pig tracheal spirals was examined in a potassium-rich solution (30 mM). Finally, their effects were studied in vivo against acetylcholine and histamine-induced bronchoconstri… Show more

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Cited by 4 publications
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“…7B). Relaxant H 2 receptors have previously been described in isolated human and guinea pig airways (Black et al, 1972;Advenier et al, 1987), but not in the IPL.…”
Section: Schultz-dale Reaction In Guinea Pig Lung 413mentioning
confidence: 99%
“…7B). Relaxant H 2 receptors have previously been described in isolated human and guinea pig airways (Black et al, 1972;Advenier et al, 1987), but not in the IPL.…”
Section: Schultz-dale Reaction In Guinea Pig Lung 413mentioning
confidence: 99%