The asymptotic behavior of the scattering amplitude for two scalar particles at high energies with fixed momentum transfers is studied. The study is done within the effective theory of quantum gravity based on quasi-potential equation. By using the modified perturbation theory, a systematic method is developed to find the leading eikonal scattering amplitudes together with corrections to them in the one-loop gravitational approximation. The relation is established and discussed between the solutions obtained by means of the operator and functional approaches applied to quasi-potential equation. The first non-leading corrections to the leading eikonal amplitude are found.