PRADELA J. Cross-cultural adaptation of the Headache Disability Inventory (HDI), validity and reliability of HDI and the Brazilian version of the Headache Impact Test (HIT-6TM) in patients with headache. [thesis]. Ribeirão Preto: University of São Paulo, Ribeirão Preto Medical School, 2020. 99p. Headache is a symptom frequently reported by patients in clinical practice and it is related to a substantial impact on patients' daily life. However, many patients have difficulties to report pain and disability levels, and these aspects are relevant in the therapeutic approach. The Headache Disability Inventory (HDI) and the Headache Impact Test (HIT-6™) are questionnaires that measure the frequency that the headache interferes in the health and well-being of the individual. However, the HDI is not translated or adapted for the Brazilian population and the HIT-6™ did not have its psychometric properties evaluated so far. Therefore, the aim of this study was to translate and to perform the crosscultural adaptation of the HDI questionnaire into Brazilian Portuguese and to evaluate the validity and reliability of HDI and HIT-6™ headaches. The sample was screened from the Headache Outpatient Clinic of the FMRP/USP with diagnosis of primary and secondary headaches according to the International Classifications of Headaches. Individuals between 18 to 65 years old and headaches at least once within the last month were included. Up to 30 patients (age 34.9; SD 11.5) were included for the cross-cultural adaptation of the HDI questionnaire and, 132 (age: 39.6; DP 12.7) and 67 (age: 36.8; DP:12.5) patients were included for the validity and reliability of the HDI and HIT-6™, respectively. The translated and adapted version of the HDI was administered in 30 patients and only 20% of them had doubts regarding the understanding and meaning of the words. Its internal consistency was 0.84, considered an optimal correlation between the questionnaire items. Thus, the version applied at the pre-test stage was defined as the final version of the questionnaire. The HDI-Brazil questionnaire showed a moderate positive correlation with the HIT-6 TM (0.67, ICC95%: 0.56 to 0.75; p<0.05) and a strong negative correlation with the SF-12 questionnaire (-0.70, ICC95%:-0.79 to-0.59; p<0.05) in the construct validity assessment. HIT-6 TM also showed a moderate negative correlation with the SF-12 questionnaire (-0.64, ICC95%:-0.72 to-0.52; p<0.05). The reliability between first and second evaluations was excellent for both the HDI-Brazil (ICC: 0.95; p<0.05) and for HIT-6 TM (ICC: 0.95; p<0.05). The HDI-Brazil and HIT-6 TM presented a standard measurement error of 2.26 and 0.70, respectively. Therefore, the HDI-Brazil and HIT-6 TM questionnaires were considered valid and reliable for the evaluation of the impact of different types of headache among the Brazilian population.