This paper introduces a novel approach for self-supervised monocular depth estimation. The model is trained on stereo–image (left–right pair) data and incorporates carefully designed perceptual image quality assessment-based loss functions for image reconstruction and left–right image difference. The fidelity of the reconstructed images, obtained by warping the input images using the predicted disparity maps, significantly influences the accuracy of depth estimation in self-supervised monocular depth networks. The suggested LPIPS (Learned Perceptual Image Patch Similarity)-based evaluation of image reconstruction accurately emulates human perceptual mechanisms to quantify the quality of reconstructed images, serving as an image reconstruction loss. Consequently, it facilitates the gradual convergence of the reconstructed images toward a greater similarity with the target images during the training process. Stereo–image pair often exhibits slight discrepancies in brightness, contrast, color, and camera angle due to factors like lighting conditions and camera calibration inaccuracies. These factors limit the improvement of image reconstruction quality. To address this, the left–right difference image loss is introduced, aimed at aligning the disparities between the actual left–right image pair and the reconstructed left–right image pair. Due to the tendency of distant pixel values to approach zero in the difference images derived from the left and right source images of stereo pairs, this loss progressively steers the distant pixel values of the reconstructed difference images toward a convergence with zero. Hence, the use of this loss has demonstrated its efficacy in mitigating distortions in distant regions while enhancing overall performance. The primary objective of this study is to introduce and validate the effectiveness of LPIPS-based image reconstruction and left–right difference image losses in the context of monocular depth estimation. To this end, the proposed loss functions have been seamlessly integrated into a straightforward single-task stereo–image learning framework, incorporating simple hyperparameters. Notably, our approach achieves superior results compared to other state-of-the-art methods, even those adopting more intricate hybrid data and multi-task learning strategies.