Relative weight at ages 10 and 16 years and risk of endometriosis: a case-control analysis

Nagle, Christina M.; Bell, Tanya; Purdie, David M.; Treloar, Susan A.; Olsen, Catherine M.; Grover, Shabnam Bhandari; Green, A.C.

doi:10.1093/humrep/dep048

Cited by 41 publications

(39 citation statements)

References 39 publications

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“…Others have observed a positive 20 or inverse 16,17,19,46 association between BMI and endometriosis. This discrepancy could be because of lack of information regarding BMI before the onset of the disease.…”

Section: Risk Factors For Endometriosis 155mentioning

confidence: 98%

“…This discrepancy could be because of lack of information regarding BMI before the onset of the disease. Nagle et al 20 collected data on BMI when women were 10-16 years of age, whereas Shah et al 18 in their large prospective study used the BMI reported by women both at the time of data collection and when they were 18 years of age. In our study, we asked for the information of BMI at the time of interview, and most women probably had a lower BMI at younger age, since BMI usually increases with age.…”

Section: Risk Factors For Endometriosis 155mentioning

confidence: 99%

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Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Saha

Kuja‐Halkola

Tornvall

et al. 2017

Journal of Women's Health

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Objectives: Despite the high prevalence of endometriosis among women of reproductive age, risk factors or markers for developing the condition remain largely unknown. Many of the published studies are based on small selected samples. We therefore investigated the relationships of reproductive and lifestyle factors with endometriosis in a large sample of Swedish female twins. Material and methods: This cross-sectional study included 28,822 women. Among these, endometriosis was reported by 1,228 women and the self-reported diagnosis was confirmed by medical records. Potential risk factors or markers for risk considered were age at menarche, level of education, body mass index (BMI), parity, oral contraceptive (OC) use, infertility, coffee consumption, smoking, and alcohol intake, which were investigated using logistic regression with crude and adjusted analyses. We performed within-pair analysis to examine the sensitivity of the results. Results: Late age at menarche and higher parity showed an inverse association and infertility showed a strong association with endometriosis. We observed positive associations with coffee consumption and smoking and an inverse association with OC use in crude analysis but not in adjusted analysis. There were no significant associations between level of education, BMI, or alcohol intake and endometriosis. Within-pair analysis showed persistent inverse association of parity and association of infertility with endometriosis. Conclusions: Our study suggests that late age at menarche and higher parity are inversely associated and infertility is strongly associated with endometriosis. Future studies are needed to explore the significance of these factors in the diagnosis of endometriosis and understanding of its etiology.

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Section: Risk Factors For Endometriosis 155mentioning

confidence: 98%

Section: Risk Factors For Endometriosis 155mentioning

confidence: 99%

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Saha

Kuja‐Halkola

Tornvall

et al. 2017

Journal of Women's Health

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“…Epidemiologic studies have consistently confirmed an inverse association between BMI and endometriosis (Cramer et al, 1986;Darrow et al, 1993;Signorello et al, 1997;Missmer et al, 2004;Parazzini et al, 2004;Ferrero et al, 2005;Hediger et al, 2005;Matalliotakis et al, 2008;Nagle et al, 2009). As leptin levels are strongly correlated with adiposity (Considine et al, 1996), one may therefore expect lower leptin levels in women with endometriosis-contrary to the results of the case-control observations to date.…”

Section: Introductionmentioning

confidence: 94%

Plasma adipokines and endometriosis risk: a prospective nested case-control investigation from the Nurses' Health Study II

Shah¹,

Correia²,

Harris³

et al. 2012

Human Reproduction

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study question: Do higher leptin levels and lower adiponectin levels predict subsequent development of endometriosis? summary answer: Plasma leptin and adiponectin levels were not associated with laparoscopically confirmed endometriosis when collected prior to disease diagnosis.what is known already: Case-control studies have identified altered levels of the inflammatory adipokines leptin and adiponectin in women with endometriosis, but it remains unclear whether inflammation results in endometriosis or whether the presence of endometriosis creates an inflammatory state. study design, size, duration: Nested, matched, case-control study within the prospective Nurses' Health Study II (NHS II) cohort. Blood samples were collected between 1996 and 1999 from 29 611 female nurses within the cohort. Women who reported endometriosis before blood collection were excluded.participants/materials, setting, methods: Plasma leptin and adiponectin levels were assayed by ELISA. Three hundred and fifty cases of laparoscopically confirmed endometriosis were matched 1:2 with 694 controls of comparable race, age, infertility history, menopausal status and time of blood draw. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models adjusting for matching factors and BMI.main results and the role of chance: After adjusting for BMI, there were no statistically significant associations between endometriosis and leptin [RR ¼ 1.2; 95% CI ¼ 0.7 -2.0; P-value, test for linear trend (P trend ) ¼ 0.72], adiponectin (RR ¼ 0.8; 95% CI ¼ 0.5-1.2; P trend ¼ 0.48) or the leptin to adiponectin ratio (RR ¼ 0.8; 95% CI ¼ 0.4 -1.4; P trend ¼ 0.14) when comparing the upper with the lower quartile. Results were unaltered when analyses were stratified by BMI or restricted to cases diagnosed ≥4 years after blood draw. To evaluate statistical significance and limit the role of chance to the gold standard of 5%, we present 95% CIs about the RRs, and for P-values calculated for linear tests of trend and tests of heterogeneity, we have set the a-level to be 0.05 (i.e. ,0.05 is considered to be statistically significant).limitations and reasons for caution: A limitation of this study is the inability to differentiate the time of endometriosis 'diagnosis' from the time of disease 'onset' due to the impossibility in identifying a precise time point at which the disease process was first initiated at a molecular or cellular level. Additional limitations include lack of information regarding stage of endometriosis and the possibility of asymptomatic disease in the control population.wider implications of the findings: The mean age at diagnosis of endometriosis in the study population is 41.7, 10 years older than the mean age of diagnosis in the general population. While this may limit the generalizability of the results, there is no reason to suspect that the association between adipokines and endometriosis risk should differ at a younger age of diagnosis in an adult population.

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“…Endometriosis has been successfully identified a novel geneenvironment interaction (96). Previous studies have described a positive relationship and inverse association between endometriosis risk and social, environmental and biological factors, as well as their interactions (97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). (102), body mass index, longchain omega-3 fatty acid consumption (101), and in utero cigarette exposure (108).…”

Section: Epidemiologymentioning

confidence: 99%

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Kobayashi

Imanaka

Nakamura

et al. 2014

Molecular Medicine Reports

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Endometriosis is a complex disease influenced by genetic, epigenetic and environmental factors. The aim of the present study was to describe genomic instability, genetic polymorphisms and their haplotype, epigenetic alterations associated with predisposition to endometriosis, and the key factors associated with endometriosis-related ovarian neoplasms. Focus has been given on the developing paradigm that epigenetic alterations or genetic mutations in endometriosis may start in utero or in adolescent and young adults. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with epigenetic, genetic and environment. Genetic/epigenetic alterations include single‑nucleotide polymorphisms (SNPs), copy number variation, loss of heterozygosity (LOH), and promoter methylation. Several genes with genetic polymorphisms analyzed in the present study tended to overlap previously reported endometriosis susceptibility genes. Retrograde menstruation leads to iron overload, which facilitates the accumulation of somatic mutations through Fenton reaction-mediated oxidative stress. The epigenetic disruption of gene expression plays an important role in the development of endometriosis through interaction with environmental changes. There seems to be at least three spatiotemporally distinct phases of the development of endometriosis: the initial phase of genetic background inherited from parents; followed by epigenetic modifications in the female offspring; and iron overload, which is subject to dynamic modulation later in life. In conclusion, the marked regulation of endometriosis susceptibility genes may stem from a mechanism responsible for epigenetic and genetic mutations based on the microenvironmental changes.

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Relative weight at ages 10 and 16 years and risk of endometriosis: a case-control analysis

Abstract: These data suggest that being overweight during late childhood is associated with the development of endometriosis; however, the results warrant confirmation in larger study populations.

Cited by 41 publications

References 39 publications

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Plasma adipokines and endometriosis risk: a prospective nested case-control investigation from the Nurses' Health Study II

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

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