Relative value of plasma copper, zinc, lipids and lipoproteins as markers for coronary artery disease

Tiber, Arthur M.; Sakhaii, M.; Joffe, Caitlin; Ratnaparkhi, Mrunal

doi:10.1016/0021-9150(86)90054-7

Cited by 30 publications

(13 citation statements)

References 30 publications

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“…The latter studies (34,35,37,38) reported a decrease in HDL-cholesterol. Most published observational studies have not found a significant relationship between serum or plasma zinc and total and HDLcholesterol (39)(40)(41). The present results show a significant positive correlation between serum zinc and these two lipid fractions, but the explained variance was less than 3%, indicating that the observed relationships are probably biologically less important.…”

Section: Discussionmentioning

confidence: 40%

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Thijs¹,

Staessen²,

Améry³

et al. 1992

Environ Health Perspect

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This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20-80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 ,umole/L, range 6.5-23.0 ,umole/L) than in women (12.6 Rmole/L, range 6.3-23.2 Rmole/L).In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = -0.10) and urinary cadmium (r = -0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = -0.11), log y-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = -0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.

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Section: Discussionmentioning

confidence: 40%

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Thijs¹,

Staessen²,

Améry³

et al. 1992

Environ Health Perspect

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“…In modelling with rats, it has been shown that Zn deficiency causes higher liver concentrations of total lipids (TL), cholesterol, TG and LDL-C, while HDL-C declined significantly in a dose-dependent manner [64]. In contrast to this study, Tiber et al [24] found no association between plasma Zn or Cu and the serum levels of lipids such as TC, TG, HDL-C, LDL-C in adult male patients with confirmed coronary artery disease. Selenium absorption and metabolism may be reduced after menopause, and this may promote cholesterol metabolism and/or decreased LDL-C receptors [54,55].…”

Section: Discussionmentioning

confidence: 72%

“…Previous studies investigating the relationship between trace elements and lipids mostly take into account the cardiovascular risk factors for humans [24,[54][55][56][57]. For the first time, this study presents data on Se, Cu, Zn and lipids in the serum of Turkish postmenopausal osteoporotic women.…”

Section: Discussionmentioning

confidence: 93%

Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Arıkan

Coşkun

Özer

et al. 2011

Biol Trace Elem Res

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It has been shown that the trace elements and lipids play role in the growth, development and maintenance of bones. We aimed to investigate serum selenium (Se), zinc (Zn), copper (Cu) and lipid (total cholesterol, triglyceride (TG), high density lipoprotein-cholesterol, low-density lipoprotein-cholesterol) levels in postmenopausal women with osteoporosis, osteopenia and in healthy controls, and to determine the relationship between Se, Zn, Cu and lipid parameters and bone mineral density (BMD). The study included 107 postmenopausal women; 35 healthy (group 1), 37 osteopenic (group 2) and 35 osteoporotic (group 3). The women in all three groups were carefully matched for body mass index (BMI). Serum concentrations of Se, Zn and Cu were measured by atomic absorption spectrophotometry. Plasma Se, Cu, Zn and lipid levels were similar in all groups (p > 0.05). When we combined the women in each of the three groups, and considered them as one group (n = 107) we found a positive correlation between BMI and lumbar vertebra BMD, femur neck BMD, femur total BMD; a positive correlation between TG and femur neck BMD, femur total BMD; a positive correlation between Zn and lumbar vertebra BMD (total T score) (p < 0.05). There was no correlation between Se, Cu, Zn, P and lipid parameters (p > 0.05). Although BMI has a positive effect on BMD, trace elements and lipids, except Zn and TG, did not directly and correlatively influence BMD. Further studies are needed to clarify the role and relationship of trace elements and lipid parameters in postmenopausal osteoporosis.

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“…In most studies including adult patients, no relationship between blood zinc and cholesterol has been found [26][27][28][29]. However, patients with marked hypercholesterolemia (8.92 ± 0.92 mmol/1 cholesterol) have been reported to have low zinc levels, a result not found in patients with milder hypercholesterolemia (7.18 ± 0.35 mmol/1) [30].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

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Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and beta-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, beta-carotene, and copper, but had lower plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. The study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis.

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Relative value of plasma copper, zinc, lipids and lipoproteins as markers for coronary artery disease

Cited by 30 publications

References 30 publications

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

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