Relative Value and Cost-Effectiveness of Culture and Special Stains in Fine Needle Aspirates of the Lung

Krane, Jeffrey F.; Renshaw, Andrew A.

doi:10.1159/000331608

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…12 However, a more recent study evaluating the cost-effectiveness of culture in FNAB of lung specimens found fungal culture to be insensitive and not-cost effective. 13 We also did not find fungal culture to be clinically useful in the patients and FNAB specimens examined.…”

Section: Discussionmentioning

confidence: 72%

Clinical significance of cultures collected from fine‐needle aspiration biopsy

Granville

Laucirica

Verstovsek

2008

Diagnostic Cytopathology

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The rate of positive cultures in fine-needle aspiration biopsy (FNAB) specimens is evaluated, and the value of submitting FNAB culture is assessed. Review of 3,300 FNAB specimens from 2,416 patients were tabulated for culture results, when obtained from the FNAB material. For positive culture results, clinical impact was assessed. Of 3,300 FNAB specimens and 2,416 patients, 185 had cultures performed (6% of specimens, 8% of patients). Of the 185 cultured specimens, 63 (34%) were positive and 122 (66%) were negative. Of the 63 positive cultures, 23 (12% of all FNAB cultures) had a significant impact on patient care. In our institution the FNA culture rate is 6%. When cases with clinical or microscopic suspicion of infection are cultured, 34% are positive for aerobic or anaerobic bacteria, mycobacteria or fungus. Culture in FNA specimens is a useful adjunct to diagnosis and impacts care in 12% of patients cultured at FNAB. This method can be used to triage patients with suspected infectious diseases and can aid in managing patients who may have recurrent infections.

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Section: Discussionmentioning

confidence: 72%

Clinical significance of cultures collected from fine‐needle aspiration biopsy

Granville

Laucirica

Verstovsek

2008

Diagnostic Cytopathology

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“…Cultures were all negative in cases in which hyphal fungi were noted on cytology. Others have noted this finding and questioned the usefulness and cost‐effectiveness of fungal culture in FNA specimens because fungi were often identified by morphology and special stains . Lack of sporulation because of conditions such as the presence of nonviable fungus balls and traumatization of cultured material during processing may contribute to poor culture results .…”

Section: Discussionmentioning

confidence: 99%

“…Others have noted this finding and questioned the usefulness and costeffectiveness of fungal culture in FNA specimens because fungi were often identified by morphology and special stains. 14,15 Lack of sporulation because of conditions such as the presence of nonviable fungus balls and traumatization of cultured material during processing may contribute to poor culture results. 16 We believe that attempting to culture organisms is warranted when fungal hyphae are identified during ROSE because mycelial fungi lacking fruiting heads cannot be identified to the genus level on the basis of morphology whereas cultures occasionally will be productive.…”

Section: Discussionmentioning

confidence: 99%

Correlation of microbiologic culture and fine‐needle aspiration cytology: A 14‐year experience at a single institution

Clement

Williams‐Bouyer

Nawgiri

et al. 2015

Cancer Cytopathology

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identified by cytology and culture, 44 (34%) were identified by culture only, and 22 (17%) were identified by cytology only. Among the 67 cases of fungi, 34 (51%) were identified by cytology only, with 15 of these 34 cases being fungal hyphae; 25 cases (37%) were identified by cytology and culture, with a 100% concordance between the cytology diagnosis and culture result; and 8 cases (12%) were identified by culture only. CONCLUSIONS: FNA cytology-culture correlation is a valuable tool with which to assess the efficacy and limitations of the direct diagnosis of infectious agents, and to identify types of infections that may be negative on culture but positive on cytology diagnosis. Cancer (Cancer Cytopathol) 2015;123:612-9.

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“…3 The methenamine silver stain is often useful in highlighting these spherules. 4,5 In the absence of the typical spherules, the presence of necrosis and reactive bronchial lining epithelial cells in aspirates can be misinterpreted as malignancy. 6,7 In such cases, a core biopsy is useful for establishing a definitive diagnosis.…”

Section: Dear Dr Bedrossianmentioning

confidence: 99%