Relative toxicity for indoor semi volatile organic compounds based on neuronal death

Abstract

For the first time, the relative in vitro toxicity of 13 indoor contaminants belonging to different chemical families has been assessed on the basis of neuronal cell viability. Lack of comparable toxicity datasets limits the number of SVOCs that can be included. More standardized protocols in terms of cell lines, species and exposure duration should be developed with a view to cumulative risk assessment.

A brief review on the mental health for select elements of the built environment

“…Furthermore, several semi-volatile organic compounds (SVOCs) include known neurotoxins that are associated with negative behavioural outcomes. 158,159 The connections between airborne toxins and mental health outcomes are of particular concern in the indoor built environment where there is a frequent use of household cleaners and chemicals with such compounds, as well as SVOCs, which are common in building materials.…”

Chemical-by-chemical and cumulative risk assessment of residential indoor exposure to semivolatile organic compounds in France

“…Finally, for RPF and TEF construction, the uncertainties mainly depend on data comparability: for example concerning different exposure routes (intratracheal, breast implants, and cutaneous contact) (Ineris 2003), endpoints (decrease in fetal testosterone level for all phthalates versus smallness -or absence of -male reproductive organs for DEHP) (Benson 2009), windows of exposure (prenatal, postnatal, and adult), and types of experimental systems (cell lines versus primary cultures), strains (mice, rats, and humans) and types of cells (e.g. pheochromocytoma versus neuroblastoma cells) (Fournier et al, 2017).…”

“…Specific effects on testosterone synthesis have also been shown following rodent exposure to PBDEs (BDE 99) and PAHs (benzo[a]pyrene) (Fournier et al, 2016). They are also known to be neurotoxic in experimental mammals, and numerous epidemiological studies suggest an association between early-life exposure to SVOCs (OCs, OPs, PCBs, PBDEs, PAHs, and phthalates) and behavioral impairment later in life (Fournier et al, 2017). PAHs (especially benzo[a]pyrene) and some OCs or OPs pesticides are also known to be carcinogenic compounds (IARC 2010;Inserm 2013).…”

“…The objective of this study, conducted within the framework of the ECOS project (Glorennec et al, 2011), was to assess the public health risk posed by 32 SVOCs. Briefly the ECOS project aimed to develop multi-residue analytical methods appropriate to indoor contamination (Mercier et al, 2012(Mercier et al, , 2014, as well as to measure indoor contamination in France (Mandin et al, 2016;Blanchard et al, 2014), group compounds on the basis of common toxicity (Fournier et al, 2014b), and develop mixture toxicity indicators (Fournier et al, 2016(Fournier et al, , 2017. Using nationwide measurements, we assessed exposure (by inhalation, contact and ingestion) to 32 indoor SVOCs on a population basis, that is, the distributions of exposure are representative of those of the population living in France (Pelletier et al, 2017b).…”

Emissions of VOCs, SVOCs, and mold during the construction process: Contribution to indoor air quality and future occupants’ exposure

“…12 SVOCs are suspected to have reprotoxic or neurotoxic effects. 13,14 They are emitted from various sources in living environments 15 and include a wide range of molecules with different properties: pesticides, biocides, plasticizers, flame retardants, surfactants, and lubricants used as active substances or additives. They are present in the gas phase, airborne particles, and settled dust 16 ; therefore, humans are exposed through different pathways including inhalation, ingestion, and dermal contact.…”