Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia

Löf-Öhlin, Zarah M.; Hagnelius, Nils-Olof; Nilsson, Torbjörn

doi:10.1097/wnr.0b013e3283089220

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…In two younger cohorts of narrow age range (mean age 47 years, and mean age 66.7 years), telomere length was not associated with changes in cognition (Mather et al, 2010). Other clinic-based cross-sctional studies have found no association of telomere length with MCI, with Mini-Mental Status Exam scores (Hochstrasser et al, 2012), or with dementia (Lof-Ohlin et al, 2008). …”

Section: Discussionmentioning

confidence: 87%

Short and long telomeres increase risk of amnestic mild cognitive impairment

Roberts

Boardman

Ruth

et al. 2014

Mechanisms of Ageing and Development

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Peripheral blood telomere length has been associated with age-related conditions including Alzheimer’s disease (AD). This suggests that telomere length may identify subjects at increased risk of AD. Thus, we investigated the associations of peripheral blood telomere length with amnestic mild cognitive impairment (aMCI), a putative precursor of AD, among Mayo Clinic Study of Aging participants who were prospectively followed for incident aMCI. We matched 137 incident aMCI cases (mean age 81.1 years, [range 70.9–90.8]; 49.6% men) by age and sex to 137 cognitively normal controls. We measured telomere length (T/S ratio) at baseline and follow-up using quantitative PCR. Compared to the middle T/S quintile (Q3), the risk of aMCI was elevated for subjects with the shortest (Q1: HR, 2.85, 95% Confidence interval [CI] 0.98, 8.25; p = 0.05) and the longest telomere lengths (Q5: HR, 5.58, 95%CI, 2.21, 14.11; p = 0.0003). In this elderly cohort, short and long telomeres were associated with increased risk of aMCI. Our findings suggest that both long and short telomere lengths may play a role in the pathogenesis of aMCI, and may be markers of increased risk of aMCI.

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Section: Discussionmentioning

confidence: 87%

Short and long telomeres increase risk of amnestic mild cognitive impairment

Roberts

Boardman

Ruth

et al. 2014

Mechanisms of Ageing and Development

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“…While it is tempting to speculate that immune senescence resulting from shorter telomeres is one reason why age is a major risk factor for many NDs, evidence supporting this view is limited. Prospective studies found that short LTL predicts dementia [48, 49], cognitive decline [50–52] and mortality [49, 53], but not the progression from mild cognitive impairment (MCI) to AD [54, 55]. Further prospective studies are needed to evaluate the predictive nature of short LTL.…”

Section: Effects Of Short Ltl On Neurodegenerationmentioning

confidence: 99%

Telomere shortening in neurological disorders: an abundance of unanswered questions

Eitan

Hutchison

Mattson

2014

Trends in Neurosciences

139

132

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Telomeres, ribonucleoprotein complexes that cap eukaryotic chromosomes, typically shorten in leukocytes with aging. Aging is a primary risk factor for neurodegenerative disease (ND), and a common assumption has arisen that leukocyte telomere length (LTL) can serve as a predictor of neurological disease. However, the evidence for shorter LTL in Alzheimer’s and Parkinson’s patients is inconsistent. The diverse causes of telomere shortening may explain variability in LTL between studies and individuals. Additional research is needed to determine whether neuronal and glial telomeres shorten during aging and in neurodegenerative disorders, if and how LTL is related to brain cell telomere shortening, and whether telomere shortening plays a causal role in or exacerbates neurological disorders.

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“…The underlying mechanisms of these interesting phenomena remain to be elucidated [134]. On the other hand, a couple of studies were unable to confirm the above association [136,137]. Lukens et al [136] found that leucocyte and cerebellum telomere lengths were directly correlated in AD patients.…”

Section: Telomere Biology and Human Aging-associated Diseasesmentioning

confidence: 99%

Healthy aging and disease: role for telomere biology?

2011

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Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

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Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia

Cited by 12 publications

References 22 publications

Short and long telomeres increase risk of amnestic mild cognitive impairment

Short and long telomeres increase risk of amnestic mild cognitive impairment

Telomere shortening in neurological disorders: an abundance of unanswered questions

Healthy aging and disease: role for telomere biology?

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