Relative survival of patients with non-malignant central nervous system tumours: a descriptive study by the Austrian Brain Tumour Registry

Wöehrer, Adelheid; Hackl, Monika; Waldhör, Thomas; Weis, Stefan; Pichler, Josef; Olschowski, A; Buchroithner, Johanna; Maier, Hans; Stockhammer, Günther; Thomé, Claudius; Haybaeck, Johannes; Payer, F.; Campe, Gord von; Kiefer, Andreas; Würtz, Franz Georg; Vince, Giles Hamilton; Sedivy, Roland; Oberndorfer, Stefan; Marhold, Franz; Bordihn, Karin; Stiglbauer, Wolfgang; Gruber-Mösenbacher, Ulrike; Bauer, Richard; Feichtinger, J.; Reiner-Concin, Angelika; Grisold, W; Marosi, Christine; Preusser, Matthias; Dieckmann, Karin; Slavc, Irene; Gatterbauer, Brigitte; Widhalm, Georg; Haberler, Christine; Hainfellner, Johannes A.

doi:10.1038/bjc.2013.714

Cited by 35 publications

(21 citation statements)

References 35 publications

(65 reference statements)

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“…Because CBTs can be malignant and have poor prognoses regardless of their histologic behavior, it is important to consistently include nonmalignant tumors in CBT surveillance studies (19)(20)(21). Moreover, the inclusion of (20); nonmalignant tumors accounted for 48% of all CBTs in this study and 39% of the those in the CBTRUS. The high incidence of CNS germ cell tumor in Korean children and adolescents is one of the key findings of our study.…”

Section: Discussionmentioning

confidence: 95%

A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data

Kang

Hong

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We investigated the epidemiologic characteristics of childhood brain tumors (CBT) in Korea, and compared our findings with those from the United States. Methods: We searched the Korea National Cancer Incidence Database of the Korea Central Cancer Registry (KCCR) from 2005 to 2014, which included all Korean patients with CBT aged 0 to 19 years at diagnosis. The age-standardized incidence rates (ASR) and the 5-year relative survival rate (RSR) were determined. The Central Brain Tumor Registry of the United States (CBTRUS) classification and definitions were applied to allow direct comparison with U.S. data. Results: A total of 6,027 CBTs were identified. The ASR of all CBTs was 5.08 per 100,000 population, which was significantly lower than that in the United States (5.57). However, the ASR of nonmalignant CBTs in Korea (2.48) was significantly higher than that in the United States (2.15). Embryonal tumors (ASR: 0.99 and 0.72 in the 0-4 and 5-9 year age groups, respectively) were the most common CBTs in these respective age groups. Germ cell tumors (0.78) and pituitary tumors (1.63) were the most common CBTs in the 10-14 and 15-19 year age groups, respectively. The 5-year RSR of CBTs was 84% and varied according to histology. Conclusions: High incidences of nonmalignant and germ cell tumors are distinct CBT features in Korean children and adolescents. Impact: To our knowledge, this is the first and largest population-based epidemiologic study of CBTs in Asia. Our findings support the notion that East Asian populations have a higher incidence of central nervous system germ cell tumors than other races.

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Section: Discussionmentioning

confidence: 95%

A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data

Kang

Hong

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Brain tumors are the most common cause of cancer-related deaths in children 1 , 2 . While brain tumors are a heterogeneous group with some fairly aggressive subtypes, advancements in imaging and therapeutic breakthroughs have increased the number of children surviving these tumors 1 , 2 . This important milestone has been offset by the emergence of co-morbidities and premature mortality in survivors 3 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study

Wang

Fleming

Johnston

et al. 2018

Sci Rep

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Children with brain tumors (CBT) are at higher risk of cardiovascular disease and type 2 diabetes compared to the general population, in which birth weight is a risk factor for these diseases. However, this is not known in CBT. The primary aim of this study was to explore the association between birth weight and body mass measures in CBT, compared to non-cancer controls. This is a secondary data analysis using cross-sectional data from the CanDECIDE study (n = 78 CBT and n = 133 non-cancer controls). Age, sex, and birth weight (grams) were self-reported, and confirmed through examination of the medical records. Body mass index (BMI) was calculated from height and weight measures and reported as kg/m2. BMI z-scores were obtained for subjects under the age of 20 years. Multivariable linear regression was used to evaluate the relationship between birth weight and BMI and BMI z-score, adjusted for age, sex, puberty, and fat mass percentage. Higher birth weight was associated with higher BMI and BMI z-score among CBT and controls. In conclusion, birth weight is a risk factor for higher body mass during childhood in CBT, and this may help the identification of children at risk of future obesity and cardiometabolic risk.

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“…Brain tumors are the most common solid tumors in children and constitute up to 20 % of childhood cancers [ 1 ]. Significant breakthroughs in understanding the hallmarks of cancer biology, coupled with advances in diagnostic imaging and improved therapies, have enhanced the survival rates of these children [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol

et al. 2016

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BackgroundPediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood brain tumors (SCBT). However, these survivors are at an increased risk of obesity and cardiometabolic disorders that affect their quality of life and lifespan. It is important to define effective strategies to treat and prevent obesity in this population. This systematic review aims to investigate the effectiveness of lifestyle interventions, pharmacotherapy, and bariatric surgery on treating obesity in SCBT.MethodsSearches will be conducted in PubMed, MEDLINE, EMBASE, PsycINFO, SPORTDiscus, CINAHL, Cochrane Database of Systematic Review, Cochrane Central Register of Controlled Trials (CENTRAL), and Database of Abstracts of Reviews of Effect (DARE). In addition, ClinicalTrials.gov and ProQuest Dissertations and Theses A&I will be searched to identify relevant gray literature. The reference lists of eligible articles will be searched for additional studies. All screening, quality assessment, and data abstraction will be done independently by two reviewers. We will perform meta-analysis if there are sufficient studies.DiscussionThis review will summarize evidence for the effectiveness of interventions used to reduce obesity risk in SCBT. This has significant implications for SCBT, as it can identify gaps in knowledge and provide insights into the development of new interventions to manage obesity in survivors, which may improve their outcomes.Systematic review registrationPROSPERO CRD42015025909Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-016-0274-9) contains supplementary material, which is available to authorized users.

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Relative survival of patients with non-malignant central nervous system tumours: a descriptive study by the Austrian Brain Tumour Registry

Cited by 35 publications

References 35 publications

A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data

A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data

Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study

The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol

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