Despite improvement in survival noted throughout the past few decades (1), patients with Marfan syndrome remain at risk for premature death secondary to the cardiovascular complications of aortic dilation and dissection (2). Risk factors for such complications remain poorly defined, thereby impeding attempts at risk stratification for the individual patient. Family history of aortic dissection (3) and spontaneous genetic mutations (4) have been identified as risk factors but, currently, no potentially modifiable risk factors have been elucidated.The underlying biomechanical abnormalities in Marfan syndrome have been well described. Patients with Marfan syndrome have reduced aortic distensibility, which becomes progressively more abnormal with increasing age (5). These biomechanical abnormalities precede the vascular complication of aortic dilation and dissection, and may reflect both endothelial and vascular smooth muscle cell abnormalities of the aortic wall (6-8).The current obesity epidemic has been the subject of much lay and scientific attention. Obesity, hyperlipidemia, smoking and hypertension have been established as clear risk factors for atherosclerotic arterial disease (9). These risk factors predispose to impaired vascular endothelial function, thereby increasing the risk of vascular complications including coronary arterial obstructive disease and stroke (10). Marfan syndrome is characteristically associated with an asthenic body habitus; as a result, these patients have been considered to be exempt from the current obesity epidemic.We sought to determine the prevalence of obesity and overweight in an adult cohort of patients with Marfan syndrome, to assess the prevalence of other cardiovascular risk factors among this patient group -namely smoking, hyperlipidemia, diabetes and hypertensionand to determine what, if any, clinical impact such risk factors had on outcome in this patient cohort.
BACKGROUND:Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. OBJECTIVE: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. METHODS: Fifty outpatients (30 female) with a mean (± SD) age of 38±13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kg/m 2 ), overweight (BMI 25 kg/m 2 to 29.9 kg/m 2 ) or obese (BMI 30 kg/m 2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. RESULTS: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4±7.4 kg/m 2 , with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hyp...