Relative seroprevalence of cysticercus antigens and antibodies and antibodies to Taenia ova in a population sample in south India suggests immunity against neurocysticercosis

Jayaraman, T.; Prabhakaran, Vasudevan; Babu, P G; Raghava, Mohan Venkata; Rajshekhar, Vedantam; Dorny, Pierre; Muliyil, Jayaprakash; Oommen, Anna

doi:10.1016/j.trstmh.2010.10.007

Cited by 30 publications

(12 citation statements)

References 29 publications

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“…In a study in India, higher infection rates (as indicated by sero Ag detection) were noted in areas with higher taeniosis prevalences [48]. Also in our study a significant positive relationship between copro-Ag positivity (presence of tapeworm) and sero-Ag positivity (cysticercosis) was established (logistic regression and cluster analysis).…”

Section: Discussionsupporting

confidence: 76%

Taenia solium Infections in a Rural Area of Eastern Zambia-A Community Based Study

et al. 2012

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Background Taenia solium taeniosis/cysticercosis is a parasitic infection occurring in many developing countries. Data on the status of human infections in Zambia is largely lacking. We conducted a community-based study in Eastern Zambia to determine the prevalence of human taeniosis and cysticercosis in a rural community.Methods and FindingsStool and serum samples were collected from willing participants. Geographical references of the participants' households were determined and household questionnaires administered. Taeniosis was diagnosed in stool samples by coprology and by the polyclonal antibody-based copro-antigen enzyme-linked immunosorbent assay (copro-Ag ELISA), while cysticercosis was diagnosed in serum by the B158/B60 monoclonal antibody-based antigen ELISA (sero-Ag ELISA). Identification of the collected tapeworm after niclosamide treatment and purgation was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A total of 255 households from 20 villages participated in the study, 718 stool and 708 serum samples were collected and examined. Forty-five faecal samples (6.3%) were found positive for taeniosis on copro-Ag ELISA while circulating cysticercus antigen was detected in 5.8% (41/708) individuals. The tapeworm recovered from one of the cases was confirmed to be T. solium on PCR-RFLP. Seropositivity (cysticercosis) was significantly positively related to age (p = 0.00) and to copro-Ag positivity (taeniosis) (p = 0.03) but not to gender. Change point analysis revealed that the frequency of cysticercus antigens increased significantly in individuals above the age of 30. Copro-Ag positivity was not related to age or gender. The following risk factors were noted to be present in the study community: free-range pig husbandry system and poor sanitation with 47.8% of the households visited lacking latrines.ConclusionsThis study has recorded high taeniosis and cysticercosis prevalences and identified the need for further studies on transmission dynamics and impact of the disease on the local people.

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Section: Discussionsupporting

confidence: 76%

Taenia solium Infections in a Rural Area of Eastern Zambia-A Community Based Study

et al. 2012

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“…(4) The prevalence of active epilepsy related to NCC varied from 1.3 to 4.5 per 1,000 population in Indian studies. (5,6,7,8) In a farming community, prevalence of 6.6% was reported for epilepsy and 18.6% for Taenia solium infection. (9) In our study, the prevalence is 4.3%.…”

Section: Resultsmentioning

confidence: 99%

Role of Ct in the Study of Prevalence of Neurocysticercosis in a Rural and Suburban Teaching Hospital

R¹,

Hegde²,

Amith³

et al. 2016

jebmh

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AIMS AND OBJECTIVES The main aim of the study was to identify the prevalence, lobar distribution of neurocysticercosis in a suburban and rural centre of southern Karnataka. Its distribution in male and female population, distribution among various age groups, distribution in lobes, describe its stages, and presence of perilesional oedema. MATERIAL AND METHODS The study was conducted in the Department of Radiodiagnosis, MVJ Medical College and Research Hospital, Bangalore, for a period of 6 yrs. from January 2009 to December 2015. Data collection was prospective. A computer-assisted search of all the reports of CT brain with the diagnosis of NCC was conducted within the departmental database. A total of 198 patients with NCC were identified and the study was conducted. RESULTS Total 4582 CT studies of brain were reviewed. 198 cases of neurocysticercosis (4.3%) were detected. 115 were males and 83 were females. The age range was 8 to 70 years with a mean age of 30 years. The number of patients under age 20 years (n=46) was more compared to the adult patients. Maximum numbers of patients were seen in 41 to 50 years age group followed by 51 to 60 years. Stage 2 of the disease was noted to be predominant in our study with 61 cases (30%) followed by stage 4. However, individual cases showing multiple stages of NCC were observed in 56 cases. Parietal lobe was more commonly involved followed by temporal, frontal, and occipital lobe. Multiple stages of the NCC in individual cases were seen in 56 cases. The presence of an eccentric enhancing scolex was noted in 57 cases. CONCLUSION The prevalence of neurocysticercosis in our study over a period of six years is 4.3% and it is more commonly observed in the paediatric age group (23.2%) and in male sex (58%).

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“…However serum IgG antibody for cysticercus was positive, which might be due to high exposure of cysticercus parasite in the general population. One of the studies from the South East Asian region found Taenia cysticercus antigens in 4.5% and positive cysticercus IgG antibodies in 15.9% of the asymptomatic population [ 14 ]. The FNAC of swelling of this patient demonstrated findings suggestive of parasitic cyst which were inconclusive in determining specific parasitic infections.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis presenting as multiple intramuscular nodules in a child: a case report

Dhakal¹,

Shah²,

Shrestha³

et al. 2015

J Med Case Reports

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IntroductionTuberculosis is a global health problem that mostly affects people in developing countries. Tuberculosis can occur in various organ systems and may present with diverse manifestations in the same system. Primary muscular tuberculosis is a very rare condition in both adults and children, and tuberculosis of various muscle groups presenting as intramuscular nodules is an even more uncommon presentation.Case presentationA 9-year-old Asian girl presented with multiple painless, gradually progressive swellings over different parts of her body for 3 months with no history of contact with tuberculosis. A physical examination was normal except for multiple swellings in her right forearm, a single swelling in her interscapular region and multiple swellings in her right calf. Ultrasonography of swellings revealed multiple nodules in the intramuscular layer. Excisional biopsies performed from two different sites revealed swellings in muscular layers and histopathology showed granulomatous inflammation with caseous necrosis consistent with tuberculosis. The child was started on antitubercular therapy after which the swellings resolved; she was kept on regular follow up.ConclusionsIntramuscular nodules in multiple muscular sites may be the presenting symptoms of tuberculosis of the muscles. Tuberculosis of skeletal muscles should be considered in a differential diagnosis when presented with single or multiple masses even when a chest X-ray is normal and there is no evidence of tubercular foci elsewhere in the body.

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Relative seroprevalence of cysticercus antigens and antibodies and antibodies to Taenia ova in a population sample in south India suggests immunity against neurocysticercosis

Cited by 30 publications

References 29 publications

Taenia solium Infections in a Rural Area of Eastern Zambia-A Community Based Study

Taenia solium Infections in a Rural Area of Eastern Zambia-A Community Based Study

Role of Ct in the Study of Prevalence of Neurocysticercosis in a Rural and Suburban Teaching Hospital

Tuberculosis presenting as multiple intramuscular nodules in a child: a case report

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