Relative reward processing in primate striatum

Cromwell, Howard C.; Hassani, Oum Kaltoum; Schultz, Wolfram

doi:10.1007/s00221-005-2223-z

Cited by 112 publications

(81 citation statements)

References 23 publications

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“…D 2 antagonist injections did not cause significant prolongation of the reaction times in the equal-reward task, but they did so for contralateral saccades on the small-reward trials in the biased-reward task. These task-dependent effects of dopamine antagonists are consistent with the task-dependent activity of caudate neurons that is sensitive to the difference in expected reward value between targets Cromwell et al, 2005).…”

Section: Discussionsupporting

confidence: 68%

Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades

Nakamura¹,

Hikosaka²

2006

J. Neurosci.

158

123

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Expected reward impacts behavior and neuronal activity in brain areas involved in sensorimotor processes. However, where and how reward signals affect sensorimotor signals is unclear. Here, we show evidence that reward-dependent modulation of behavior depends on normal dopamine transmission in the striatum. Monkeys performed a visually guided saccade task in which expected reward gain was different depending on the position of the target. Saccadic reaction times were reliably shorter on large-reward trials than on smallreward trials. When position-reward contingency was switched, the reaction time difference changed rapidly. Injecting dopamine D 1 antagonist into the caudate significantly attenuated the reward-dependent saccadic reaction time changes. Conversely, injecting D 2 antagonist into the same region enhanced the reward-dependent changes. These results suggest that reward-dependent changes in saccadic eye movements depend partly on dopaminergic modulation of neuronal activity in the caudate nucleus.

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Section: Discussionsupporting

confidence: 68%

Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades

Nakamura¹,

Hikosaka²

2006

J. Neurosci.

158

123

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“…Our meta-analysis first identified a consistent involvement of the VS and vmPFC in downward comparison. Based on the role of these regions in reward processing [Carlson et al, 2011;Cromwell et al, 2005;McClure et al, 2004;Rushworth et al, 2011;Sescousse et al, 2015], our findings dovetail with the notion that downward comparison is experienced as rewarding [Bault et al, 2011;Dvash et al, 2010;Fliessbach et al, 2007]. Prior studies have shown the involvement of the VS in the processing of other types of social rewards, including good reputation [Izuma et al, 2008;Meshi et al, 2013] and social approval [Izuma et al, 2010].…”

Section: Discussionsupporting

confidence: 85%

Social comparison in the brain: A coordinate‐based meta‐analysis of functional brain imaging studies on the downward and upward comparisons

Luo

Eickhoff

Hétu

et al. 2017

Human Brain Mapping

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Social comparison is ubiquitous across human societies with dramatic influence on people's well-being and decision making. Downward comparison (comparing to worse-off others) and upward comparison (comparing to better-off others) constitute two types of social comparisons that produce different neuropsychological consequences. Based on studies exploring neural signatures associated with downward and upward comparisons, the current study utilized a coordinate-based meta-analysis to provide a refinement of understanding about the underlying neural architecture of social comparison. We identified consistent involvement of the ventral striatum and ventromedial prefrontal cortex in downward comparison and consistent involvement of the anterior insula and dorsal anterior cingulate cortex in upward comparison. These findings fit well with the "common-currency" hypothesis that neural representations of social gain or loss resemble those for non-social reward or loss processing. Accordingly, we discussed our findings in the framework of general reinforcement learning (RL) hypothesis, arguing how social gain/loss induced by social comparisons could be encoded by the brain as a domain-general signal (i.e., prediction errors) serving to adjust people's decisions in social settings. Although the RL account may serve as a heuristic framework for the future research, other plausible accounts on the neuropsychological mechanism of social comparison were also acknowledged. Hum Brain Mapp 39:440-458, 2018.V C 2017 Wiley Periodicals, Inc.

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“…We note that studies of the NAc and caudal VP have demonstrated electrophysiological coding of taste hedonic reward (Cromwell et al, 2005;Roitman et al, 2005;Tindell et al, 2006) and reported opioid-related bidirectional interaction between NAc and VP sites (Hakan et al, 1994;Panagis et al, 1997;Napier and Mitrovic, 1999). Also, conceivably, the hedonic NAc-VP circuit identified here might also mediate the hedonic effects of opioid agents on subjective ratings of food palatability in humans (Yeomans and Gray, 1996;Drewnowski, 1997).…”

Section: Discussionmentioning

confidence: 56%

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Smith¹,

Berridge²

2007

J. Neurosci.

400

307

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-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake ("wanting"), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions.

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Relative reward processing in primate striatum

Cited by 112 publications

References 23 publications

Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades

Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades

Social comparison in the brain: A coordinate‐based meta‐analysis of functional brain imaging studies on the downward and upward comparisons

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

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