Relative quantitative proteomic profiling of bovine colostrum and transition milk at onset of lactation

Masterson, Hannah K.; O'Callaghan, Tom F.; O'Donovan, Michael; Murphy, John Paul; Sugrue, Katie; Owens, Rebecca A.; Hickey, Rita M.

doi:10.1016/j.idairyj.2023.105804

Cited by 5 publications

(1 citation statement)

References 80 publications

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“…Furthermore, the supplementation of bovine colostrum to infants improves the digestive and absorptive functions, and ameliorates gut inflammation via the recovery of systemic immunity [5]. Although several studies have investigated the proteomic profiles of bovine colostrum [6][7][8] and mature milk [9,10] individually, there is a dearth of research into the comparison of these profiles to reveal the delicate differences in proteins enriched in each milk type. Therefore, it is of great importance to uncover and compare the protein profiles of bovine colostrum and mature milk, which may provide a better understanding of the nutritional values of infant formula, and also contribute to the development of infant formula with superior nutritional quality.…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Proteomic Profiles of Bovine Colostrum and Mature Milk Derived from the First and Second Lactations

Feng,

Shen,

Fan

et al. 2023

Foods

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Bovine colostrum (BC) and mature bovine milk are highly nutritious. In addition to being consumed by adults, these dairy products are also used as protein ingredients for infant formula. However, the differences in the nutritional composition of BC and mature milk, especially regarding proteins present in trace amounts, have not been comprehensively studied. Furthermore, the distinct proteomic profiles of mature milk derived from the first lactation (Milk-L1) and the second lactation (Milk-L2) are not fully understood. To address these gaps, this study aims to uncover the subtle differences in protein compositions of BC, Milk-L1, and Milk-L2 by proteomics. Compared with BC, anti-microbial proteins β-defensins and bovine hemoglobin subunit were up-regulated in Milk-L1, while Milk-L2 exhibited higher levels of enteric β-defensin, sterol regulatory element binding transcription factor 1, sydecan-2, and cysteine-rich secretory protein 2. Additionally, immune proteins such as vacuolar protein sorting-associated protein 4B, polymeric immunoglobulin receptor (PIGR), and Ig-like domain-containing protein were found at higher levels in Milk-L1 compared with Milk-L2. The study provides a comprehensive understanding of the distinct proteomic profiles of BC, Milk-L1, and Milk-L2, which contributes to the development of protein ingredients for infant formula.

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Section: Introductionmentioning

confidence: 99%

Unravelling the Proteomic Profiles of Bovine Colostrum and Mature Milk Derived from the First and Second Lactations

Feng,

Shen,

Fan

et al. 2023

Foods

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Colostrum in cheese milk: Effects on physicochemical and microbiological characteristics of milk, whey and fresh cheese

Sánchez-Macías,

Herrera-Chávez,

Quevedo-Barreto

et al. 2024

International Dairy Journal

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Bovine Colostrum and Its Management in UK Dairy Herds

Lindley

2024

Animal Science Cases

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At birth, the calf has a naïve immune system and is reliant upon maternal antibodies until it begins to produce its own. Gut absorption of these antibodies may be facilitated by the consumption of colostrum soon after birth, a process described as the “transfer of passive immunity”. Additional components found within colostrum, such as maternal leucocytes, microRNAs, hormones and oligosaccharides also contribute to calf health and development. These compounds stimulate intestinal epithelial cell development and the establishment of a healthy gut microbiome, which may enhance antibody absorption, inhibit pathogens and modulate immune responses. Different methods of colostrum collection, storage, handling and feeding will influence how colostrum is consumed and absorbed, and an appreciation of these factors is essential. Information © The Author 2024

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Relative quantitative proteomic profiling of bovine colostrum and transition milk at onset of lactation

Cited by 5 publications

References 80 publications

Unravelling the Proteomic Profiles of Bovine Colostrum and Mature Milk Derived from the First and Second Lactations

Unravelling the Proteomic Profiles of Bovine Colostrum and Mature Milk Derived from the First and Second Lactations

Colostrum in cheese milk: Effects on physicochemical and microbiological characteristics of milk, whey and fresh cheese

Bovine Colostrum and Its Management in UK Dairy Herds

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