Relative Potency of Amethocaine and Lignocaine

Newer anesthetics end their uses

“…194 The absolute potency of a local anesthetic drug is probably best described in terms of its ability to produce blockage of large myelinated neurones (motor and proprioceptive) at a dose level which is free from any toxic reactions. 210 The toxicity of local anesthetics can be simply demonstrated in man by administering the drugs intravenously at rates proportional to the concentrations in which they are employed for the production of regional anesthesia and recording the dos es that produce hypotension, apnea, and muscle twitching. Also, changes in the electrocardiogram, electroencephalogram, and methemoglobinemia should be recorded.…”