Relative levels of IL4 and IFN-γ in complicated malaria: Association with IL4 polymorphism and peripheral parasitemia

Association of Early Interferon‐γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean Children

“…Blood collected at baseline was diluted 1:1 in PBS, and PBMCs were separated by density centrifugation with Ficoll-Paque PLUS (Amersham). PBMCs were washed, resuspended at cells/mL in 80% fetal bovine 7 1 ϫ 10 serum and 20% dimethyl sulfoxide, frozen to Ϫ80ЊC at 1ЊC per min in freezing containers (Nalgene), and transferred to liquid N 2 .…”

Influence of functional genetic polymorphism (−590C/T) in non-small cell lung cancer (NSCLC) development: The paradoxal role of IL-4

“…The T allele increases IL-4 expression and is associated with elevation of total serum levels of IL-4, whereas the C allele is associated with lower gene expression (Rosenwasser et al, 1995). The frequencies of the T "high expression" allele range between 70% and 85% in Asians and 15% and 25% in Europeans (Anovazzi et al, 2010;Chiang et al, 2007;Gyan et al, 2004;Hegab et al, 2004;Heward et al, 2001;Holla et al, 2008;Huang et al, 2008;Kawashima et al, 1998;Kim et al, 2007;Landi et al, 2007;Nunez et al, 2008;Rosenwasser et al, 1995;Tangteerawatana et al, 2007;Tsezou et al, 2008;Vairaktaris et al, 2007;Yannopoulos et al, 2007;Zhu et al, 2010). This allele has been associated with some types of cancer (Huang et al, 2008;Vairaktaris et al, 2007;Varin and Gordon, 2009).…”

Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels

“…Moreover, elevated levels of IFN-␥ in the acute phase of uncomplicated P. falciparum malaria has been shown to limit progression to clinical malaria (59). Studies in Thai adults demonstrated significantly higher IFN-␥ levels in uncomplicated malaria than in individuals presenting with complicated malaria (56). In addition, a previous longitudinal study with a pediatric population in western Kenya demonstrated that high levels of circulating IFN-␥ were associated with enhanced SMA severity in a pediatric population (46).…”