Relative inhibitory activity of bile acids against 12-<I>O</I>-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis

Abstract

This is the first report on the anti-inflammatory activity of bile acids on TPA-induced inflammatory ear oedema in mice. Chenodeoxycholic acid, methyl 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oate and methyl 3alpha,7alpha,15beta-trihydroxy-5beta-cholan-24-oate showed the most potent activity, at a level corresponding to that of hydrocortisone. Furthermore, chenodeoxycholic acid markedly inhibited tumour promotion in a two-stage carcinogenesis model in mouse skin.

Design and synthesis of bile acid derivatives and their activity against colon cancer

“…1 Numerous studies have shown that BA derivatives have many biological functions, such as anti-tumor (Fig. 1), 2–8 anti-inflammatory, 9–11 antibacterial, 12–15 antiviral, 16,17 regulation of metabolism, and so on. Some BA derivatives (Fig.…”