Relative Inhibition of Thrombin Activatable Fibrinolytic Inhibitor by Newly Developed Thrombin Inhibitors: Impact on Bleeding and Antithrombotic Actions.
Abstract:Thrombin activatable fibrinolytic inhibitor (TAFI) acts as an inhibitor of fibrinolysis by cleaving the arginine and lysine amino acid residues from the carboxy terminus of fibrin, rendering it resistant to digestion by plasmin. This study determines the effect of direct thrombin inhibitors on TAFI functionality and if there is a correlation to their anti‐IIa effects. The following thrombin inhibitors were tested: argatroban, melagatran, angiomax, LU 208791, hirudin and dabigatran. All agents were supplemented… Show more
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