Relative incidences and outcomes of Clostridium difficile infection following transplantation of unrelated cord blood, unrelated bone marrow, and related peripheral blood in adult patients: a single institute study

Abstract

These data indicate that the incidence and prognosis of CDAD after uCBT are comparable with those after uBMT and rPBSCT.

A multicenter, retrospective, case‐cohort study of the epidemiology and risk factors for Clostridium difficile infection among cord blood transplant recipients

“…This study represents the largest cohort of UCBT recipients with CDI and demonstrates a 100‐day CDI rate of 10.2% and a 1‐year CDI rate of 13.3%. Two smaller studies have evaluated CDI in this population documenting overall CDI rates ranging from 9% to 25% . These rates appear consistent with the 12.5%‐26.9% range documented in the literature for recipients of allogeneic HSCT (allo‐HSCT) .…”

“…Historically, infections represent a leading cause of morbidity and mortality in this population. In small series, UCBT recipients appear to have substantial rates of CDI, approaching 25% of UCBT recipients, which may be a reflection of overall immune suppression including delay in T‐cell function, iatrogenic immune suppression caused by chemotherapeutics, therapies to treat and prevent graft‐versus‐host‐disease (GVHD), and hypogammaglobulinemia related to underlying disease and transplantation. Immune dysfunction may contribute to the overall host risk that is likely to include additional factors, such as prolonged healthcare exposure, receipt of broad‐spectrum antibiotics, and receipt of chemotherapeutic agents.…”

Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation

“…A meta-analysis of 17 trials and 1453 patients concluded that antibiotic prophylaxis reduced the incidence of fever and bacteremia, but did not impact all-cause or infection-related mortality 28 . C. difficile (C. Diff) was not a focus of our study, but other investigators have reported similar incidence and recovery from C. Diff infections after UCBT, MRD, or MUD 29 .…”

Evaluation of Risk Factors forClostridium difficileInfection in Hematopoietic Stem Cell Transplant Recipients

“…Of the 550 patients who underwent HCST during the study period, 6% (35/550 patients) subsequently developed CDI. Within the literature, the incidence of CDI after all HSCT ranges from 3–17% . A higher incidence of CDI is reported among patients who underwent allogeneic HSCT .…”

“…Within the literature, the incidence of CDI after all HSCT ranges from 3-17%. 8,[19][20][21][22][23] A higher incidence of CDI is reported among patients who underwent allogeneic HSCT. 19,24,25 In our study, we also found that most patients who underwent HSCT and who developed CDI had undergone an allogeneic HSCT.…”