Relative Importance of ?? and ?? Adrenergic Receptors during Resuscitation

Yakaitis, Ronald W.; Otto, C. W.; Blitt, Casey D.

doi:10.1097/00132586-198004000-00061

Cited by 27 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 He further concluded that the value of epinephrine was not in its direct action on the heart, but rather in its action on the peripheral vasculature. More recently, studies by Yakaitis and coworkers 10 have confirmed Redding's studies. Prior to experimental asphyxial arrest, dogs were pre-treated with drugs producing either alpha-or beta-receptor blockade.…”

Section: Peripheral Vascular Tonementioning

confidence: 62%

“…In fact, the use of isoproterenol, a pure beta agonist, resulted in no survivors, an outcome worse than that in the saline-treated control group. A subsequent study by Yakaitis et al 10 (Yakaitis was Redding's former student) obtained no better results with the somewhat selective  1 agonist, dobutamine. Redding repeatedly tested the use of calcium chloride incardiac arrest and found it to be inferior to epinephrine in restoring the circulation.…”

Section: Peripheral Vascular Tonementioning

confidence: 93%

“…These studies showed that alpha blockade, but not beta blockade, significantly decreased the incidence of survival following cardiac arrest and CPR. [10][11][12][13] …”

Section: Peripheral Vascular Tonementioning

confidence: 99%

See 2 more Smart Citations

Joseph S. Redding's contributions to cardiac resuscitation

Ralston

Babbs

1985

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Section: Peripheral Vascular Tonementioning

confidence: 62%

Section: Peripheral Vascular Tonementioning

confidence: 93%

See 1 more Smart Citation

Joseph S. Redding's contributions to cardiac resuscitation

Ralston

Babbs

1985

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

“…All animals were weaned off drug infusion between 4 and 8 minutes after defibrillation. After weaning and without further blood pressure support, the transient rise in mean aortic pressure remained elevated for a longer duration in the phenylephrine group (Figure 1).…”

Section: Heartmentioning

confidence: 99%

“…(Circulation 1989;79:1332-1342 pinephrine has been the primary choice of E pressor agents used during cardiopulmonary resuscitation (CPR), although agents with pure a-adrenergic agonism have also been advocated. [1][2][3][4] Epinephrine is known to improve other hand, epinephrine can increase the strength of fibrillatory contractions and myocardial 02 demand while limiting subendocardial blood flow.1" In contrast, methoxamine increases the ratio of subendocardial to subepicardial blood flow during openchest CPR.11 With regard to the brain, cerebral 02 demand also may be stimulated by central ,Badrenoceptors if sufficient epinephrine crosses the blood-brain barrier.12,13 Stimulation of 02 demand at a time when blood flow is limited could have an adverse effect on recovery, but a recent study contrasting the effects of epinephrine and phenylephrine administration in dogs 9 minutes after fibrillation failed to detect differences in neurologic deficit 24 hours later.14 However, the limited number of surviving animals largely remained behaviorally impaired at 24 hours, which made it difficult to show that one particular drug had an adverse effect on cortical function.…”

mentioning

confidence: 99%

Organ blood flow and somatosensory-evoked potentials during and after cardiopulmonary resuscitation with epinephrine or phenylephrine.

et al. 1989

View full text Add to dashboard Cite

Pure a-adrenergic agonists, such as phenylephrine, and mixed ax-and ,B-adrenergic agonists, such as epinephrine, raise perfusion pressure for heart and brain during cardiopulmonary resuscitation (CPR). However, with the high doses used during CPR, these drugs may directly affect vascular smooth muscle and metabolism in brain and heart. We determined whether at equivalent perfusion pressure, continuous infusion of phenylephrine (20 ug/kg/min) or epinephrine (4 ,ug/kg/min) leads to equal organ blood flow, cerebral 02 uptake, and cerebral electrophysiologic function. During 20 minutes of CPR initiated immediately upon ventricular fibrillation in anesthetized dogs, left ventricular blood flow was similar with epinephrine (45±9 ml/min/100 g) or phenylephrine (47±8 ml/min/100 g) infusion. The ratio of subendocardial to subepicardial blood flow fell equivalently during CPR with either epinephrine (1.23±0.06 to 0.70±0.05) or phenylephrine (1.32±0.07 to 0.77±0.05) administration. At similar levels of cerebral perfusion pressure (44 ±3 mm Hg), similar levels of cerebral blood flow were measured in both groups (27±3 ml/min/100 g). Cerebral 02 uptake was maintained at prearrest levels in both groups. Somatosensory-evoked potential amplitude was modestly reduced during CPR, but it promptly recovered after defibrillation. During CPR and at 2 hours after resuscitation, there were no differences between drug groups in the level of regional cerebral or coronary blood flow, cerebral 02 uptake, or evoked potentials. Therefore, with minimal delay in the onset of CPR and with equipotent pressor doses of phenylephrine and epinephrine, we found no evidence that one agent provides superior coronary or cerebral blood flow or that epinephrine by virtue of its 8-adrenergic properties adversely stimulates cerebral metabolism at a critical time that would impair brain electrophysiologic function. Moreover, epinephrine did not preferentially impair subendocardial blood flow as might be expected if it enhanced the strength of fibrillatory contractions. (Circulation 1989;79:1332-1342 pinephrine has been the primary choice of E pressor agents used during cardiopulmonary resuscitation (CPR), although agents with pure a-adrenergic agonism have also been advocated.1-4 Epinephrine is known to improve From the

show abstract

Pericardial tamponade during balloon pulmonary valvuloplasty in a dog

Wieser

Ringer

Toaldo

2021

Vet Record Case Reports

View full text Add to dashboard Cite

A 4-month-old entire male Coton de Tulear dog was referred for balloon valvuloplasty for treatment of severe valvular pulmonic stenosis. During the procedure, when attempting to pass the guide wire into the ventricle, the dog developed cardiac arrest. After initial resuscitation with chest compressions, manual ventilation, adrenaline and intravenous fluids, focused cardiac ultrasound revealed pericardial effusion and cardiac tamponade. Pericardiocentesis resolved the haemodynamic emergency. This case report should raise awareness of pericardial tamponade as a possible complication during pulmonic stenosis balloon valvuloplasty. It describes the clinical signs observed during anaesthesia as well as how to treat it with a positive outcome.

show abstract

Relative Importance of ?? and ?? Adrenergic Receptors during Resuscitation

Cited by 27 publications

References 0 publications

Joseph S. Redding's contributions to cardiac resuscitation

Joseph S. Redding's contributions to cardiac resuscitation

Organ blood flow and somatosensory-evoked potentials during and after cardiopulmonary resuscitation with epinephrine or phenylephrine.

Pericardial tamponade during balloon pulmonary valvuloplasty in a dog

Contact Info

Product

Resources

About