Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus

Sola-Rodríguez, Sergio; Vargas‐Hitos, José Antonio; Gavilán‐Carrera, Blanca; Rosales-Castillo, Antonio; Sabio, José Mario; Hernández‐Martínez, Alba; Martínez-Rosales, Elena; Ortego‐Centeno, Norberto; Soriano‐Maldonado, Alberto

doi:10.3390/ijerph18094630

Cited by 4 publications

(7 citation statements)

References 48 publications

(59 reference statements)

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“…Our results revealed that there are certain measures of burden that have been poorly evaluated in recent literature, such as the burden of treatment, disability, health care utilization, work participation, and, clearly, economic burden [ 13 , 28 ]. Most studies to date that have attempted to assess the impact of obesity and diabetes on the health outcomes of SLE patients have a cross-sectional design, so causality cannot be inferred [ 15 , 19 , 29 , 30 , 31 ]. This has determined that the role of obesity and diabetes in SLE remains poorly understood [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…For optimal prevention and treatment of atherosclerosis, it is not self-evident that women and men show similar responses to risk factors or treatment; therefore, studies must present results according to sex. Whether the threat and risk factors of premature atherosclerosis in women with SLE are generalized to male patients is unknown [ 3 , 26 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Obesity, Diabetes, and Cardiovascular Risk Burden in Systemic Lupus Erythematosus: Current Approaches and Knowledge Gaps—A Rapid Scoping Review

Hernández-Negrín

Ricci

Mancebo-Sevilla

et al. 2022

IJERPH

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Obesity, diabetes mellitus, and cardiovascular risk are real challenges in systemic lupus erythematosus (SLE) clinical practice and research. The evidence of the burden of these health problems in SLE patients is determined by the methods used to assess them. Therefore, the aim of this scoping review is to map current approaches in assessing obesity, diabetes mellitus, and cardiovascular risk burden in SLE patients and to identify existing knowledge gaps in this field. This rapid scoping review was conducted according to the Joanna Briggs Institute methodology and identified 274 articles, of which 73 were included. Most studies were conducted at European institutions and patients were recruited from specialist hospital clinics, the majority of whom were women. The burden of obesity and diabetes mellitus for SLE patients was assessed mainly in terms of prevalence, impact on disease activity, and cardiometabolic risk. The burden of cardiovascular risk was assessed using multiple approaches, mainly imaging and laboratory methods, and risk factor-based scores, although there is great heterogeneity and uncertainty between the methods used. This review highlights the importance of improving and standardizing the approach to obesity, diabetes, and cardiovascular risk in SLE patients through a holistic assessment that includes lifestyle, clinical, biological, and social aspects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obesity, Diabetes, and Cardiovascular Risk Burden in Systemic Lupus Erythematosus: Current Approaches and Knowledge Gaps—A Rapid Scoping Review

Hernández-Negrín

Ricci

Mancebo-Sevilla

et al. 2022

IJERPH

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“… 4 Weaker hand grip strength has been observed in adults with SLE relative to non-SLE comparators, 5 and weaker hand grip is associated with higher cardiometabolic risk when adjusted for body mass index (BMI). 6 …”

Section: Introductionmentioning

confidence: 99%

Association of phenotypic frailty and hand grip strength with telomere length in SLE

Lieber,

Lipschultz,

Syed

et al. 2024

Lupus Sci Med

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ObjectiveFrailty and objective hand grip strength (one of the components of the frailty phenotype) are both risk factors for worse health outcomes in SLE. Whether telomere length, an established cellular senescence marker, is a biologic correlate of the frailty phenotype and hand grip strength in patients with SLE is not clear. First, we aimed to evaluate differences in telomere length between frail and non-frail women with SLE and then assessed whether frailty or hand grip strength is differentially associated with telomere length after adjusting for relevant confounders.MethodsWomen ≥18 years of age with validated SLE enrolled at a single medical centre. Fried frailty status (which includes hand grip strength), clinical characteristics and telomere length were assessed cross-sectionally. Differences between frail and non-frail participants were evaluated using Fisher’s exact or Wilcoxon rank-sum tests. The associations between frailty and hand grip strength and telomere length were determined using linear regression.ResultsOf the 150 enrolled participants, 131 had sufficient data for determination of frailty classification; 26% were frail with a median age of 45 years. There was a non-significant trend towards shorter telomere length in frail versus non-frail participants (p=0.07). Hand grip strength was significantly associated with telomere length (beta coefficient 0.02, 95% CI 0.004, 0.04), including after adjustment for age, SLE disease activity and organ damage, and comorbidity (beta coefficient 0.02, 95% CI 0.002, 0.04).ConclusionsDecreased hand grip strength, but not frailty, was independently associated with shortened telomere length in a cohort of non-elderly women with SLE. Frailty in this middle-aged cohort may be multifactorial rather than strictly a manifestation of accelerated ageing.

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“…In general population, higher levels of muscle strength have shown to be related to a lower risk of developing cardiovascular disease [ 22 ], type 2 diabetes [ 20 ], fragility [ 23 ] and mortality [ 24 ]. Specifically, handgrip strength (HGS), and HGS relative to the body mass index (BMI), have been proposed as highly relevant health indicators in different populations, such as young and older adults [ 25 ], adult males [ 26 ], aging adults [ 27 ], women with systemic lupus erythematosus [ 28 ], and women with fibromyalgia [ 29 ]. HGS and relative HGS (rHGS) have also been proposed as a cardiometabolic risk predictor in children and adolescents [ 30 ] and in middle-aged and older people [ 31 , 32 ], and as an all-cause [ 33 , 34 , 35 ] and cancer [ 36 ] mortality predictor, allowing to obtain useful information from a simple, quick, and very low-cost assessment.…”

Section: Introductionmentioning

confidence: 99%

“…RHGS is a good indicator of general health in different populations. For instance, higher levels of rHGS are associated with greater mobility in older adults [ 46 , 47 ], better cardiovascular health in obese women [ 48 ], lower prevalence of metabolic syndrome in adults [ 49 ], lower prevalence of osteoporosis in women [ 50 ], lower cardiometabolic risk in women with systemic lupus erythematosus [ 28 ], and lower risk of depressive mood in women [ 39 ]. Therefore, we speculated that higher rHGS would be related to better self-reported physical function and HRQoL in female breast cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

Absolute and Relative Handgrip Strength as Indicators of Self-Reported Physical Function and Quality of Life in Breast Cancer Survivors: The EFICAN Study

Esteban-Simón

Díez-Fernández

Artés-Rodríguez

et al. 2021

Cancers

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Background: Although breast cancer (BC) is the most prevalent type of cancer in the world, its high survival rate implies that many people live long after the treatments and face their side effects. The physical function (PF) and health-related quality of life (HRQoL) of people surviving BC decreases significantly, which makes important to identify markers that may be associated with a better health status and prognosis. Previous studies suggest that handgrip strength (HGS) and HGS relative to the body mass index (rHGS) are good indicators of PF and HRQoL in different populations. However, it is unknown whether this applies to BC survivors. This study aimed to evaluate the association of HGS and rHGS with PF and HRQoL in this population. Methods: Sixty female BC survivors participated. Handgrip strength was assessed with a dynamometer. Arm volume was estimated and upper limb impairments, as well as cancer-related fatigue, depression, life satisfaction and HRQoL, were assessed using standardized questionnaires. Results: Higher levels of HGS and rHGS were associated with higher levels of HRQoL, lower cancer-related fatigue, and fewer problems with the affected arm. Conclusions: These results suggest that HGS may be a good indicator of self-reported PF and HRQoL in female BC survivors.

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Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus

Cited by 4 publications

References 48 publications

Obesity, Diabetes, and Cardiovascular Risk Burden in Systemic Lupus Erythematosus: Current Approaches and Knowledge Gaps—A Rapid Scoping Review

Obesity, Diabetes, and Cardiovascular Risk Burden in Systemic Lupus Erythematosus: Current Approaches and Knowledge Gaps—A Rapid Scoping Review

Association of phenotypic frailty and hand grip strength with telomere length in SLE

Absolute and Relative Handgrip Strength as Indicators of Self-Reported Physical Function and Quality of Life in Breast Cancer Survivors: The EFICAN Study

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