Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population

Abstract

Notable incidence of obesity and dysfunction of adiposity tissue is strongly presented in type 2 diabetes mellitus (T2DM) worldwide. Relative Fat Mass (RFM) is anew, simple and inexpensive marker of whole body fat that predicts diabetes, dyslipidemia and dysglycemia as cardio-metabolic disorders. The current study aimed to evaluate the clinical applications of RFM as an obesity marker to predict the diabetes and to evaluate metabolic disorders associated with development of T2DM. The study was conducted on 118 adult patients with T2DMand on 51 healthy individuals seen at Tishreen University Hospital (TUH) and Diabetes Center of Lattakia city- Syria. Results confirm that RFM is higher in females than males with ratio of 1.5. Strong significant association of RFM withelevated levels of lipid profile-parameters, glycated-hemoglobin (HbA1c)> 8% and eGFR between 30-44ml/min/1.73m2 is seen as uncontrolled T2DM patients (P-value<0.05). RFM can predict diabetes with cutoff value of 33.60 (AUC: 0.77, sensitivity of 72% and Specificity of 100%) in comparison with healthy control, and with cutoff value of 40 with (AUC:0.92, sensitivity of 85% and Specificity of 93%) in females in comparison with males. In conclusion, this study has demonstrated that RFM is a whole body fat marker which significantly associated with obesity, gender and cardio-metabolic disorders in T2DM.