Relative contributions of negative symptoms, insight, and coping strategies to quality of life in stable schizophrenia

Montemagni, Cristiana; Castagna, Filomena; Crivelli, Barbara; Marzi, Giampiero De; Frieri, Tiziana; Macrì, Antonio; Rocca, Paola

doi:10.1016/j.psychres.2014.07.019

Cited by 35 publications

(31 citation statements)

References 124 publications

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“…Consistent with this, better clinical insight was correlated with better personal and social skills 65 and prosocial behavior 66 . Montemagni et al 67 found that clinical insight predicted the capacity for social connectedness and may mediate the relationship of negative symptoms to social function. Tastet et al 68 reported that better insight predicted a range of indices of higher levels of community function, including frequency of social contact and perceived social support.…”

Section: Insight and Outcomementioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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Section: Insight and Outcomementioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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“…The Baron and Kenny approach was selected because it is a well-established approach to mediation analysis and has been used across a number of recent studies within the psychiatric literature (du Prel et al, 2014; Montemagni et al, 2014; Pagani et al, 2014; Parveen et al, 2014; Wicke et al, 2014; Yiaslas et al, 2014; du Prel and Peter, 2015; Park et al, 2015; Soltero et al, 2015; Yoshikawa et al, 2015; Barbui et al, 2016; Barth et al, 2016; Lepnurm et al, 2016; Oh and Kim, 2016). This approach tests the zero-order relationships between the independent variable (IV), depression, the dependent variable (DV), serum LDL changes, and the potential mediators (M).…”

Section: Methodsmentioning

confidence: 99%

Serum lipid changes following the onset of depressive symptoms in postmenopausal women

Persons

Robinson

Payne

et al. 2017

Psychiatry Research

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A cross-sectional association between depression and serum low-density lipoprotein cholesterol (LDL-c) has been noted in psychiatric literature, raising the question of temporality: does low LDL-c predict depression, does depression lead to changes in LDL-c levels, or is this relationship bidirectional? In a previous longitudinal analysis of postmenopausal women ages 50–79 who participated in the Women’s Health Initiative (WHI), we detected an association between low LDL-c and the subsequent onset of depressive symptoms (HR=1.25, 95% CI 1.05–1.49, p=0.01). This current study uses the WHI cohort to explore the question of temporality in the opposite direction, examining the influence of depressive symptoms on subsequent changes in LDL-c levels. This study provides no evidence to suggest an association between depression and subsequent changes in LDL-c level (−2.78 mg/dL, 95% CI= −7.49 to 1.92, p=0.25), nor was any association detected for total cholesterol, HDL, or triglyceride changes over time. Further, this study demonstrates that the relationship between depression and serum LDL changes is not mediated by changes in weight, exercise, or energy intake.

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“…delusions, hallucinations, conceptual disorganization) the self-perceived QoL cannot be reliably measured; thus, samples exclude these patients and that might well explain the weak, though significant, positive symptom -QoL association. Negative symptoms influence QoL [17,39,41,[43][44][45], even more than positive symptoms [35,43]. It has been observed that the association between negative symptoms and QoL is related primarily to experiential deficits (i.e.…”

Section: Comparison Of Correlations Between Symptom Dimensions and Sumentioning

confidence: 99%

“…asociality, anhedonia, amotivation), highlighting the importance of differentiate subdomains in the negative dimension [39]. Also, cognitive deficits and insight (usually included in the general psychopathology dimension) seem to have an important role in this association; yet, only for those with severe negative symptoms [41,44]. Therefore, it seems that negative symptoms, at a high level, relates to QoL but it does through the indirect effect of other related symptoms from the general psychopathology dimension.…”

Section: Comparison Of Correlations Between Symptom Dimensions and Sumentioning

confidence: 99%

Comparison of Correlations between Symptom Dimensions and Subjective Quality Of Life in Mexican Outpatients with Psychosis

Gómez-de-Regil¹,

Rubio-Zapata²,

Estrella-Castillo³

2018

Neuropsychiatry

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Objective: Research in psychosis has supported a close association betweeen symptoms and QoL (Quality of Life), but a direct comparison between the associations of symptom dimensions with QoL is needed. The present study expanded upon previous studies by 1) analyzing the association between clinical symptomatology and quality of life in a sample of Mexican patients with psychosis and 2) exploring whether one particular symptom dimension (positive, negative, general) is significantly more strongly correlated with quality of life than the others by comparing correlations from the same sample. Method: Psychopathology and quality of life of 61 outpatients with a diagnosis of schizophrenia or related psychosis were assessed with the PANSS (Positive and Negative Syndrome Scale) and the CSCV (Seville Questionnaire) scales, respectively. The strength of the resulting PANSS-CSCV Spearman correlations was compared with the cocor statistical package. Results: The three symptom dimensions (positive, negative and general psychopathology) were significantly related to quality of life. Correlation comparisons confirmed that general psychopathology had not only results that are more significant but also stronger correlations with quality of life in comparison to both, positive and negative symptoms. Conclusions: In outpatients whose overall symptoms have ameliorated, general psychopathology symptoms play a more significant role in the self-perceived QoL. A comprehensive treatment must include psychosocial interventions focused on general psychopathology to enhance the prospect of patients' recovery.

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Relative contributions of negative symptoms, insight, and coping strategies to quality of life in stable schizophrenia

Cited by 35 publications

References 124 publications

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Serum lipid changes following the onset of depressive symptoms in postmenopausal women

Comparison of Correlations between Symptom Dimensions and Subjective Quality Of Life in Mexican Outpatients with Psychosis

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