Relative contribution of antipsychotics, negative symptoms and executive functions to social functioning in stable schizophrenia

Rocca, Paola; Montemagni, Cristiana; Castagna, Filomena; Giugiario, Michela; Scalese, Mara; Bogetto, Filippo

doi:10.1016/j.pnpbp.2009.01.002

Cited by 36 publications

(24 citation statements)

References 85 publications

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“…Social functioning prior and at illness onset could be an important marker for long-term prognosis for negative symptoms. Several studies have also shown that negative symptoms predict difficulties in functioning socially within schizophrenia (Buchanan, 2007;Pratt et al, 2005;Rocca et al, 2009). Other factors associated with poor negative symptom trajectories were having a schizophrenia diagnosis, higher disorganized symptoms at baseline and receiving standard treatment within the first two years of diagnosis.…”

Section: Negative Symptom Trajectoriesmentioning

confidence: 99%

Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort

Austin

Mors

Budtz‐Jørgensen

et al. 2015

Schizophrenia Research

157

131

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Section: Negative Symptom Trajectoriesmentioning

confidence: 99%

Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort

Austin

Mors

Budtz‐Jørgensen

et al. 2015

Schizophrenia Research

157

131

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“…This includes patients suffering from their first psychotic episode [32,33,34] and those who are antipsychotic-naïve [35]; even the healthy relatives of schizophrenic patients have been found to have executive function impairments when compared with control subjects [36,37,38]. The importance of executive functions has also been noted in recent studies that have highlighted their relevance regarding functional outcomes [39,40,41,42] and suggested their potential use as diagnostic criteria for schizophrenia [43,44]. …”

Section: Introductionmentioning

confidence: 99%

Negative Symptoms and Executive Function in Schizophrenia: Does Their Relationship Change with Illness Duration?

et al. 2012

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Background: Negative symptoms and cognitive dysfunction are of crucial functional and prognostic importance in schizophrenia. However, the nature of the relationship between them and the factors that may influence it have not been well established. Aims: To investigate whether the relationship between negative symptoms and executive function changes according to the duration of illness in schizophrenia. Methods: The Positive and Negative Syndrome Scale was used to assess psychopathology and the Wisconsin Card Sorting Test (WCST) to evaluate executive function in a sample of 200 schizophrenic patients who were classified in 3 groups according to their duration of illness: up to 5 years (short duration group), 6-20 years (intermediate duration group) and over 20 years of illness (long duration group). Results: Medium-sized correlations were found between negative symptoms and WCST performance as assessed by the number of completed categories in all 3 groups. However, differences were found according to the duration of schizophrenia. For patients in the short duration group, negative symptoms correlated with WCST nonperseverative errors, but for those in the long duration group the correlation was with perseverative errors. Conclusion: We found a differential relationship between negative and cognitive symptoms in different stages of schizophrenia. Illness duration should be considered when studying the relationship between negative symptoms and cognition.

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“…It is characterized by difficulties in achieving life milestones, including independent living, employment, and stable interpersonal relationships. Recent literature data suggested that several factors may influence the functional outcome in real world, in particular quality of life, adherence to treatments and severity of psychiatric symptoms [7,8,28,29]. The aim of the present study was to identify whether several Predictors of Real-World Functioning Improvement in a Sample of Psychiatric Outpatients variables, including psychiatric symptoms, onset and duration of illness, hospitalizations, suicide attempts, attitude to treatments, pharmacotherapy, psychotherapy, and subjective perception of quality of life, are predictive of the change of the global measure of real-world functioning during one year of usual outpatient treatment in a large sample of subjects with a diagnosis of schizophrenia, bipolar disorders, major depression, or borderline personality disorder.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Real-World Functioning Improvement in a Sample of Psychiatric Outpatients

Bellino¹,

Bozzatello²,

Montemagni³

et al. 2018

Neuropsychiatry

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Objective: the aim was to identify in 511 outpatients, with diagnoses of schizophrenia, major depressive disorder (MDD), bipolar disorders (BD), and borderline personality disorder (BPD), what clinical variables predict the improvement of real-world functioning during 12 months of usual treatment.Methods: sociodemographic variables were evaluated. Patients were assessed at baseline and endpoint with: Clinical Global Impression Scale -Severity (CGI-S); Satisfaction Profile (SAT-P), Drug Attitude Inventory-10 (DAI-10), and Personal and Social Performance (PSP). Statistical analysis was performed with Chi-square test and Pearson's correlation. Significant variables were included in a multiple regression analysis. Dependent variable was the difference of PSP after one year (ΔPSP). P ≤ 0.05 was significant.Results: in the total sample, ΔPSP was related to age of onset, SAT-P and psychotherapy and inversely related to suicide attempts and CGI-S. In schizophrenia, ΔPSP was related to SAT-P and DAI-10 and inversely related to CGI-S. In MDD, ΔPSP was related to SAT-P and psychotherapy and inversely related to suicide attempts and CGI-S. In BD, ΔPSP was related to SAT-P and inversely related to CGI-S. In BPD, only psychotherapy was related to ΔPSP. Conclusion:Symptoms severity predicted a worse community functioning in the total sample and in each group, except for BPD. Suicide attempts were inversely associated to functional improvement in the total sample and depression. Quality of life was related to the change of functioning in each group, except for BPD. Patients with MMD and BPD receiving psychotherapy gained a better functional improvement. Attitude to pharmacotherapy was related to functional improvement only in schizophrenia.

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Relative contribution of antipsychotics, negative symptoms and executive functions to social functioning in stable schizophrenia

Cited by 36 publications

References 85 publications

Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort

Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort

Negative Symptoms and Executive Function in Schizophrenia: Does Their Relationship Change with Illness Duration?

Predictors of Real-World Functioning Improvement in a Sample of Psychiatric Outpatients

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