1983
DOI: 10.1016/s0031-9422(00)80106-5
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Relative configuration of the alkaloid augustamine

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1984
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Cited by 23 publications
(8 citation statements)
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“…Augustamine ( 2 ) has an octahydroindole core similar to that of amabiline. Augustamine was isolated from Crinum augustum in 1981 and characterized in 1983, and interest in its pharmacological properties persists . Its absolute configuration was not assigned.…”
Section: Syntheses Of (−)-Amabiline and (−)-Augustaminementioning
confidence: 99%
“…Augustamine ( 2 ) has an octahydroindole core similar to that of amabiline. Augustamine was isolated from Crinum augustum in 1981 and characterized in 1983, and interest in its pharmacological properties persists . Its absolute configuration was not assigned.…”
Section: Syntheses Of (−)-Amabiline and (−)-Augustaminementioning
confidence: 99%
“…We consequently decided to verify in vitro the activity of six alkaloids isolated from C. amabile , augustamine ( 22 ), augustine ( 13 ), augustine N -oxide ( 1 ), buphanisine ( 8 ), buphanisine N -oxide ( 2 ) and crinine ( 10 ), against four different protozoa, Trypanosoma brucei rhodesiense , Trypanosoma cruzi , Leishmania donovani and Plasmodium falciparum , which are related to sleeping sickness, Chagas disease, visceral leishmaniasis and malaria, respectively. These alkaloids are structurally very similar, with the exception of augustamine, which is a unique kind of Amaryllidaceae alkaloid previously isolated from other Crinum species, including C. augustum , C. kirkii and C. latifolium [ 28 , 31 , 32 ], and completely elucidated in 2000 [ 33 ]. The rareness of this structure motivated us to isolate it and check its biological activity.…”
Section: Resultsmentioning
confidence: 99%
“…(synonym Crinum x amabile Donn ex Ker Gawl.) [48], a preliminary screen showed it to be inactive against Molt4 T-lymphoma cells [52]. More recently, interest in the cytotoxic properties of these compounds has been rekindled [50,51].…”
Section: The Augustamine Groupmentioning
confidence: 99%
“…[40]. The first part of the study involved the isolation of 7 alkaloids, including the 2 montanine analogs nangustine (48) and pancracine (49) [40]. Normal L6 mouse myoblasts were utilized in the second aspect of the study to measure the cytotoxicities of the isolated compounds [40].…”
Section: The Montanine Groupmentioning
confidence: 99%