Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan

Yan, Gabriel; Ang, Alicia; Tham, Sai Meng; Ng, Alvin; Chew, Ka Lip

doi:10.3201/eid2701.203312

Cited by 3 publications

(1 citation statement)

References 2 publications

(3 reference statements)

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“…These patients were significantly older (median age 62 vs. 49 years) and presented with significantly higher maximum temperatures (median temperature 39.3 vs. 38.7 °C) compared with patients with fever and an appropriate heart rate response [46]. A retrospective analysis from Japan demonstrated similar findings, where the predicted change in pulse rate was 7.37 bpm for each 1 °C increase in body temperature, as opposed to the expected rise of 18 bpm [47]. These findings have yet to be reproduced in large-scale studies, and the effect that antipyretic administration may have had on results is unclear.…”

Section: Arrhythmiasmentioning

confidence: 86%

Coronavirus disease 2019 and cardiovascular diseases: collateral damage?

Pillai

Lawson

2021

Current Opinion in Anaesthesiology

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Purpose of review Cardiovascular involvement in coronavirus disease 2019 (COVID-19) is relatively common and portends an increased risk of morbidity and mortality. Manifestations of myocardial injury may exhibit significant overlap and result in diagnostic uncertainty. This review will summarize recent literature around cardiovascular complications of COVID-19. Recent findings Venous thromboembolism, atrial fibrillation, and type II myocardial infarction are observed commonly in COVID-19, while severe acute respiratory syndrome coronavirus 2 viral myocarditis remains quite rare. Although infrequent, COVID-19 vaccination has been associated with myocarditis and pericarditis in young individuals. Summary Various forms of COVID-19-related myocardial injury have been associated with increased utilization of mechanical ventilation, hemodynamic deterioration, and mortality. Manifestations of myocardial injury in COVID-19 are varied, but share common drivers of illness including sequelae of sepsis, immune-mediated factors, and a prothrombotic state. Understanding the forms of myocardial injury in COVID-19 may aid in rapid diagnosis and treatment.

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Section: Arrhythmiasmentioning

confidence: 86%

Coronavirus disease 2019 and cardiovascular diseases: collateral damage?

Pillai

Lawson

2021

Current Opinion in Anaesthesiology

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Relative bradycardia in patients with moderate-to-severe COVID-19: a retrospective cohort study

Yoshizane

Ishihara

Mori

et al. 2022

SN Compr. Clin. Med.

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Coronavirus-related disease (COVID-19) can result in relative bradycardia; however, there are no reports on relative bradycardia in patients with moderate-to-severe COVID-19 who require oxygen. We retrospectively investigated 45 patients with moderate-to-severe COVID-19 and examined the relationship between heart rate and body temperature at the time of initiating oxygen or mechanical ventilation. For three consecutive days after initiating oxygen therapy, body temperature (day’s highest temperature), heart rate, and other vital signs were measured simultaneously. We checked for relative bradycardia and analyzed the differences between patients with moderate COVID-19 (oxygen requirement ≤ 5 L/min) and those with severe COVID-19 (oxygen requirement ≥ 5 L/min). Of the 45 patients, 28 and 17 had moderate and severe COVID-19, respectively. The heart rate increased with increasing body temperature, and almost all patients satisfied the criteria of relative bradycardia. In Spearman’s rank correlation analysis, body temperature was significantly correlated with heart rate ( ρ = 0.483, p = 0.012) in moderately ill patients but not in severely ill patients ( ρ = 0.261, p = 0.297). Multiple regression analysis revealed that the severity of COVID-19 and body temperature were independent predictors of heart rate. The predicted change in heart rate was 6.0 beats/min for each 1 °C rise in body temperature. Relative bradycardia was suggested to be a characteristic finding in patients with moderate-to-severe COVID-19 who require oxygen. Additionally, severely ill patients were more likely to develop relative bradycardia than moderately ill patients. Focusing on the relationship between heart rate and body temperature might help clinicians diagnose this disease in patients with worsening respiratory failure.

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One Year on: An Overview of Singapore’s Response to COVID-19—What We Did, How We Fared, How We Can Move Forward

Anand

Shuy

Lee³

et al. 2021

IJERPH

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Background—One year has passed since the first COVID-19 case in Singapore. This scoping review commemorates Singaporean researchers that have expanded the knowledge on this novel virus. We aim to provide an overview of healthcare-related articles published in peer-reviewed journals, authored by the Singapore research community about COVID-19 during the first year of the pandemic. Methods—This was reported using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) protocol. It included healthcare-related articles about COVID-19 published between 23 January 2020 and 22 January 2021 with a Singapore-affiliated author. MEDLINE, Embase, Scopus, Web of Science, CINAHL, PsycINFO, Google Scholar, and local journals were searched. The articles were screened independently by two reviewers. Results—The review included 504 articles. Most of the articles narrated the changes to hospital practice (210), while articles on COVID-19 pathology (94) formed most of the non-narrative papers. Publications on public health (61) and the indirect impacts to clinical outcomes (45) were other major themes explored by the research community. The remaining articles detailed the psychological impact of the pandemic (35), adaptations of medical education (30), and narratives of events (14). Conclusion—Amidst a resurgence of community cases involving variant COVID-19 strains, the resources from the research community will provide valuable guidance to navigate these uncertain times.

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Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan

Cited by 3 publications

References 2 publications

Coronavirus disease 2019 and cardiovascular diseases: collateral damage?

Coronavirus disease 2019 and cardiovascular diseases: collateral damage?

Relative bradycardia in patients with moderate-to-severe COVID-19: a retrospective cohort study

One Year on: An Overview of Singapore’s Response to COVID-19—What We Did, How We Fared, How We Can Move Forward

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