Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams

Suzuki, Masao; Kase, Yoko; Yamaguchi, H.; Kanai, Tatsuaki; Andō, Kōichi

doi:10.1016/s0360-3016(00)00568-x

Cited by 208 publications

(202 citation statements)

References 47 publications

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“…The results of the present study were consistent with a previous canine cell line study (21). Additionally, several other previous studies using human and rodent cells have demonstrated that high LET heavy ions are more effective for cell killing at identical physical absorbed doses as low LET radiation types (10)(11)(12)21,26). In general, a large number of complex clusters of DNA damage generated by high LET radiation would be more difficult to repair, resulting in more severe biological damage than that induced by low LET radiation (28,29).…”

Section: Discussionsupporting

confidence: 82%

“…For heavy ion exposure, accelerated ions were irradiated using the Heavy Ion Medical Accelerator in Chiba (HIMAC; Chiba, Japan) at room temperature. The details concerning the beam characteristics of the particle radiation, biological irradiation procedures and dosimetry have been described previously (12,25,26). Accelerated monoenergetic iron ions have 500 MeV/nucleon of initial energy and 200 keV/µm of LET at the irradiated position.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the extent of cell killing by heavy ions is not cell cycle dependent and is not decreased due to the presence of hypoxia (14)(15)(16). In human oncology, the relative biological effectiveness (RBE) is used to describe the increase in effectiveness of particle radiation (10,12). RBE is defined as the ratio of doses of photons and charged particles inducing the same biological endpoints, including cell killing, mutation and cytogenetic aberrations.…”

Section: Introductionmentioning

confidence: 99%

“…Carbon ions have increased ionization density [high linear energy transfer (LET) properties], and heavy ions differ from protons or photons with low LET due to their radiobiological properties. A number of in vitro studies have demonstrated that high LET radiation is more effective than low LET radiation in terms of cell-killing effects (10)(11)(12)(13). Additionally, the extent of cell killing by heavy ions is not cell cycle dependent and is not decreased due to the presence of hypoxia (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

et al. 2016

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Abstract. Heavy ions, characterized by high linear energy transfer (LET) radiation, have advantages compared with low LET protons and photons in their biological effects. The application of heavy ions within veterinary clinics requires additional background information to determine heavy ion efficacy. In the present study, comparison of the cell-killing effects of photons, protons and heavy ions was investigated in canine osteosarcoma (OSA) cells in vitro. A total of four canine OSA cell lines with various radiosensitivities were irradiated with 137 Cs gamma-rays, monoenergetic proton beams, 50 keV/µm carbon ion spread out Bragg peak beams and 200 keV/µm iron ion monoenergetic beams. Clonogenic survival was examined using colony-forming as says, and relative biological effectiveness (RBE) values were calculated relative to gamma-rays using the D 10 value, which is determined as the dose (Gy) resulting in 10% survival. For proton irradiation, the RBE values for all four cell lines were 1.0-1.1. For all four cell lines, exposure to carbon ions yielded a decreased cell survival compared with gamma-rays, with the RBE values ranging from 1.56-2.10. Iron ions yielded the lowest cell survival among tested radiation types, with RBE values ranging from 3.51-3.69 observed in the three radioresistant cell lines. The radiosensitive cell line investigated demonstrated similar cell survival for carbon and iron ion irradiation. The results of the present study suggest that heavy ions are more effective for killing radioresistant canine OSA cells when compared with gamma-rays and protons. This markedly increased efficiency of cell killing is an attractive reason for utilizing heavy ions for radioresistant canine OSA.

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Section: Discussionsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

et al. 2016

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“…While in vitro studies suggested, for the same kind of ion species, heavy ion-induced cell killing effect is of LET dependency (Aoki et al, 2000). Study on the RBE values of carbon ion irradiations relative to X-rays for reproductive cell death showed LET dependent cell killing effects with the RBE values ranging from 1.06 to 1.33 for 13 keV/micrometer and from 2.00 to 3.01 for approximate 77 keV/micrometer irradiation (Suzuki et al, 2000c). For the different ion species, it was also reported that the cell killing effects varied with differences in the energy deposition track structures of the different ion sources, being of LET and ion species dependence: RBE for carbon ions increased steeply up to around 98 keV/micrometer (4.07), while the neon, silicon and iron ions showed maximum peaks around 180 keV/micrometer (3.03 to 3.39) (Tsuruoka et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

X-Ray-Induced Radioresistance Against High-LET Radiations from Accelerated Neon-Ion Beams in Mice

Wang¹,

Tanaka²,

Ninomiya³

et al. 2012

Current Topics in Ionizing Radiation Research

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Significance of concurrent use of weekly cisplatin in carbon‐ion radiotherapy for locally advanced adenocarcinoma of the uterine cervix: A propensity score‐matched analysis

et al. 2019

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Background Although carbon‐ion radiotherapy (C‐ion RT) with concurrent chemotherapy (chemo‐C‐ion RT) is a promising treatment for adenocarcinoma (AC) of the uterine cervix, its long‐term efficacy remains unclear. We evaluated the long‐term significance of concurrent weekly cisplatin and C‐ion RT for locally advanced AC of the uterine cervix. Methods We performed a pooled analysis of patients with stage IIB–IVA AC of the uterine cervix who underwent C‐ion RT alone or chemo‐C‐ion RT between September 2007 and December 2018 at our institution. Patients received 74.4 Gy (relative biological effectiveness) with or without cisplatin (40 mg/m2 per week for up to 5 weeks), underwent no prior pelvic RT or systemic therapy, and had a performance status of 0‐2. Propensity score matching was based on the year of diagnosis, regional lymph node metastasis, and stage. Results The matched cohort contained 26 patients who underwent C‐ion RT and 26 who underwent chemo‐C‐ion RT. The median age and follow‐up period were 57 (range, 28‐79) years and 34 (range, 2‐126) months, respectively. The 5‐year overall survival rate was significantly better in the chemo‐C‐ion RT group (72%) than in the C‐ion RT group (46%; P = .041). The 5‐year distant metastatic‐free rate was also significantly better in the chemo‐C‐ion RT group (66%) than in the C‐ion RT group (41%; P = .048). The incidence of grade ≥ 3 late toxicities was comparable between the two groups. Conclusions Chemo‐C‐ion RT for locally advanced AC of the uterine cervix is associated with a long‐term survival benefit.

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Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams

Cited by 208 publications

References 47 publications

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

X-Ray-Induced Radioresistance Against High-LET Radiations from Accelerated Neon-Ion Beams in Mice

Significance of concurrent use of weekly cisplatin in carbon‐ion radiotherapy for locally advanced adenocarcinoma of the uterine cervix: A propensity score‐matched analysis

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