Relative Bioavailability and Pharmacokinetics: A Combination of Pentazocine and Acetaminophen

Preparation and Evaluation of Combination Tablet Containing Incompatible Active Ingredients

“…[1][2][3][4][5][6][7][8] But at the same time, there also exist some problems in the process of preparing such combination solid dosage forms, such as incompatibility between the active ingredients or between the active ingredients and excipients, which result in toxic or no clinical effects. [9][10][11][12][13][14][15][16][17][18] Therefore, how to prevent this incompatibility and design dosage forms of these drugs that are easy to use has become the focus of such development.…”